S-(2-羟基-5-硝基苄基)-6-硫鸟嘌呤
S-(2-羟基-5-硝基苄基)-6-硫鸟嘌呤结构式
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常用名 | S-(2-羟基-5-硝基苄基)-6-硫鸟嘌呤 | 英文名 | s-(2-hydroxy-5-nitrobenzyl)-6-thioguanosine |
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| CAS号 | 41094-07-9 | 分子量 | 450.42600 | |
| 密度 | 1.96g/cm3 | 沸点 | 919.8ºC at 760 mmHg | |
| 分子式 | C17H18N6O7S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 510.1ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Inhibitors of nucleoside transport. A structure-activity study using human erythrocytes.
J. Med. Chem. 18 , 968, (1975) The passage of nucleosides across the plasma membrane of erythrocytes is a membrane-mediated process which is strongly inhibited by derivatives of 9-beta-D-ribofuranosylpurine (1) with S, O, or N atoms at the purine 6 position bearing variously substituted ar... |
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Neurotensin stimulates Cl(-) secretion in human colonic mucosa In vitro: role of adenosine.
Gastroenterology 119(2) , 348-57, (2000) Previous studies indicated that the peptide neurotensin (NT) stimulates Cl(-) secretion in animal small intestinal mucosa in vitro. In this study, we investigated whether NT causes Cl(-) secretion in human colonic mucosa and examined the mechanism of this res... |
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Mechanism of urate production by guinea-pig ileum.
Adv. Exp. Med. Biol. 195 Pt B , 239-43, (1986)
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Potentiation of methotrexate lymphocytotoxicity in vitro by inhibitors of nucleoside transport.
Br. J. Cancer 59(3) , 381-4, (1989) Modulation of nucleic acid antimetabolite cytotoxicity by preformed purines and pyrimidines may not only complicate the interpretation of drug sensitivity tests and other in vitro studies but also adversely affect treatment in vivo. Previously we reported tha... |
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The effect of pH on interaction of nitrobenzylthioinosine and hydroxynitrobenzylthioinosine with the nucleoside transporter of human erythrocyte membranes.
Mol. Pharmacol. 27(6) , 662-5, (1985) Site-specific binding to human erythrocyte membranes of nitrobenzylthioinosine (NBMPR), un-ionized at physiological pH, was compared with that of hydroxynitrobenzylthioinosine (HNBMPR), pKa 6.4, at graded pH values. Binding of [3H]NBMPR was measured directly,... |
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Adenosine and ATP effects on isolated guinea pig gallbladder.
Pflugers Arch. 399(1) , 42-5, (1983) Effects of adenosine, ATP and several derivatives of adenosine were measured in isolated strips of guinea pig gallbladder. Adenosine caused relaxations which were antagonized by theophylline and potentiated by an inhibitor of adenosine uptake, 6-(1-hydroxy-5-... |
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Characterization of [3H]Ro 5-4864 binding sites in rat vas deferens.
J. Neurochem. 58(1) , 39-45, (1992) The presence of benzodiazepine binding sites in rat vas deferens was detected using [3H]Ro 5-4864 as a radioligand. The binding of [3H]Ro 5-4864 to the mitochondrial sites is saturable, reversible, and temperature and time dependent. The association rate cons... |
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Effect of arylazido aminopropionyl ATP (ANAPP3), on ATP responses of isolated guinea pig smooth muscle.
Life Sci. 30(3) , 259-67, (1982) Arylazido aminopropionyl ATP (ANAPP3), a photoaffinity analogue of adenosine 5'-triphosphate, photoactivated with visible light (+hv), specifically and irreversibly antagonized ATP contractions of the guinea pig vas deferens. ANAPP3 (30 microM) antagonized re... |
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Further characterization of an adenosine transport system in the mitochondrial fraction of rat testis.
Eur. J. Pharmacol. 398(1) , 31-9, (2000) Previous work from our laboratory has demonstrated the presence of high-affinity binding sites for [3H]nitrobenzylthioinosine ([3H]NBTI), a marker of adenosine uptake systems, in the mitochondrial fraction of rat testis. Here, we characterize this system func... |
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Adenosine uptake inhibitors potentiate the sedative effects of adenosine.
Neurosci. Lett. 36(2) , 169-74, (1983) A major action of adenosine is the induction of profound behavioral inactivity. 6-(4-Nitrobenzyl)-thioinosine (NBI) and 6-(2-hydroxy-5-nitrobenzyl)-thioguanosine (NBG) have been shown to inhibit adenosine uptake. To investigate the possible synergism between ... |