更昔洛韦
更昔洛韦结构式
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常用名 | 更昔洛韦 | 英文名 | Ganciclovir |
|---|---|---|---|---|
| CAS号 | 82410-32-0 | 分子量 | 255.231 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | 657.0±65.0 °C at 760 mmHg | |
| 分子式 | C9H13N5O4 | 熔点 | 250°C | |
| MSDS | 中文版 美版 | 闪点 | 351.1±34.3 °C | |
| 符号 |
GHS08 |
信号词 | Danger |
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Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility.
J. Virol. 89(8) , 4636-44, (2015) DNA polymerases of the Herpesviridae and bacteriophage RB69 belong to the α-like DNA polymerase family. In spite of similarities in structure and function, the RB69 enzyme is relatively resistant to foscarnet, requiring the mutation V478W in helix N to promot... |
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Thymidine kinase gene delivery using curcumin loaded peptide micelles as a combination therapy for glioblastoma.
Pharm. Res. 32(2) , 528-37, (2015) The effect of the combination therapy of curcumin and the herpes simplex virus thymidine kinase (HSVtk) gene using R7L10 as a carrier was evaluated in a glioblastoma animal model.Curcumin was loaded into the cores of R7L10 peptide micelles using an oil-in-wat... |
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Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection.
J. Exp. Med. 211(6) , 1197-213, (2014) Competition for iron influences host-pathogen interactions. Pathogens secrete small iron-binding moieties, siderophores, to acquire host iron. In response, the host secretes siderophore-binding proteins, such as lipocalin 24p3, which limit siderophore-mediate... |
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Liquid chromatography tandem mass spectrometry quantitation of intracellular concentrations of ganciclovir and its phosphorylated forms.
Anal. Bioanal. Chem 407(12) , 3449-56, (2015) Ganciclovir (GCV) is prescribed for cytomegalovirus infection which is a major issue in immunodepressed patients. It is however characterized by hematological toxicity. A better understanding of GCV concentration-effects relationships implies the measurement ... |
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Statins demonstrate a broad anti-cytomegalovirus activity in vitro in ganciclovir-susceptible and resistant strains.
J. Med. Virol. 87(1) , 141-53, (2014) Vasculoprotective and cholesterol-lowering properties are hallmarks of statins. Recently, statins have been found to exhibit antiviral activity. Little is known about the potential of statins against human cytomegalovirus (HCMV), a risk factor in the pathogen... |
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De Novo proteome analysis of genetically modified tumor cells by a metabolic labeling/azide-alkyne cycloaddition approach.
Mol. Cell. Proteomics 13(12) , 3446-56, (2014) Activin receptor type II (ACVR2) is a member of the transforming growth factor type II receptor family and controls cell growth and differentiation, thereby acting as a tumor suppressor. ACVR2 inactivation is known to drive colorectal tumorigenesis. We used a... |
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Development of a convenient ex vivo model for the study of the transcorneal permeation of drugs: histological and permeability evaluation.
J. Pharm. Sci. 104(1) , 63-71, (2014) In this paper, an ex vivo model for the study of the transcorneal permeation of drugs, based on porcine tissues, was evaluated. The setup is characterized by ease of realization, absence of O₂ and CO₂ bubbling and low cost; additionally, the large availabilit... |
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Eliminating antibiotic prophylaxis for intravitreal injections: a consecutive series of 18,839 injections by a single surgeon.
Retina (Philadelphia, Pa.) 35(4) , 783-8, (2015) By optimizing the protocol for intravitreal injections, the risk of endophthalmitis can be minimized. This study assesses the incidence of endophthalmitis and other complications after a consecutive series of intravitreal injections where all antibiotics were... |
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An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.
PLoS ONE 9(5) , e97415, (2014) We present an optimized triple modality reporter construct combining a far-red fluorescent protein (E2-Crimson), enhanced firefly luciferase enzyme (Luc2), and truncated wild type herpes simplex virus I thymidine kinase (wttk) that allows for sensitive, long-... |
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RhoB is a component of the human cytomegalovirus assembly complex and is required for efficient viral production.
Cell Cycle 14 , 2748-63, (2015) Human Cytomegalovirus (HCMV), an ubiquitous β-herpesvirus, is a significant pathogen that causes medically severe diseases in immunocompromised individuals and in congenitally infected neonates. RhoB belongs to the family of Rho GTPases, which regulates diver... |