Ganciclovir

Modify Date: 2024-01-02 14:11:27

Ganciclovir structure	Common Name	Ganciclovir
	CAS Number	82410-32-0	Molecular Weight	255.231
	Density	1.8±0.1 g/cm3	Boiling Point	657.0±65.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₃N₅O₄	Melting Point	250°C
	MSDS	Chinese USA	Flash Point	351.1±34.3 °C
	Symbol	GHS08	Signal Word	Danger

Use of Ganciclovir

Ganciclovir is a potent herpes simplex virus (HSV)inhibitor, including cytomegalovirus (CMV), with an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).

Name	ganciclovir
Synonym	More Synonyms

Description	Ganciclovir is a potent herpes simplex virus (HSV)inhibitor, including cytomegalovirus (CMV), with an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
Target	IC50: 5.2 μM (FHV-1)[1]
In Vitro	Ganciclovir is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir[2].The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase.Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[3].
In Vivo	In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice[4].
Animal Admin	Rats: Two albino rats non-immunized for MCMV are used in the study. After being weighed, two adult rats undergo peritoneal injections. The first rat receives 50 mg/kg of ganciclovir twice a day (i.e. 100 mg/kg/day), for a total of 3 days or 6 injections. The second rat is used as a negative control and received intraperitoneal injections of glucose solution. After the 6th injection, the two rats are sacrified; blood and perilymphatic fluids are collected for analysis[4]. Mice: Non-inbred Oncins France 1 (OF1) mice are used in the study. Ganciclovir is diluted in 5% glucose serum to a concentration of 5 mg/mL and administered intraperitoneally in newborn mice at a dose of 50 mg/kg twice a day. Five injections are administered in total[4].
References	[1]. Maggs DJ, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [2]. Fletcher CV, et al. Evaluation of ganciclovir for cytomegalovirus disease. DICP. 1989 Jan;23(1):5-12. [3]. Matthews T, et al. Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 1988 Jul-Aug;10 Suppl 3:S490-4. [4]. BoujemLa I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016 Aug;132:111-5.

Density	1.8±0.1 g/cm3
Boiling Point	657.0±65.0 °C at 760 mmHg
Melting Point	250°C
Molecular Formula	C₉H₁₃N₅O₄
Molecular Weight	255.231
Flash Point	351.1±34.3 °C
Exact Mass	255.096756
PSA	139.28000
LogP	-3.62
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.761
Storage condition	2-8°C
Water Solubility	0.1 M HCl: 10 mg/mL

Ganciclovir MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8407000

CHEMICAL NAME :: Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-

CAS REGISTRY NUMBER :: 82410-32-0

LAST UPDATED :: 199109

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H13-N5-O4

MOLECULAR WEIGHT :: 255.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 38,281,1986

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P280-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R46;R60;R61
Safety Phrases	S53-S36/37/39-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MF8407000
HS Code	2933990090

Precursor 9
CAS#:86357-14-4 Triacetyl-ganci... CAS#:82410-31-9 9-[[2-(benzylox... CAS#:1219792-39-8 2-(2-amino-1,6-... CAS#:73-40-5 Guanine
CAS#:74564-16-2 1,1'-[[2-(Chlor... CAS#:84960-04-3 ganciclovir CAS#:82410-30-8 N2-acetyl-9-[[1... CAS#:18602-85-2 2,6,9-tris(trim...
CAS#:100675-29-4 N2-acetyl-9-((1...
DownStream 8
CAS#:194159-18-7 Ganciclovir Mon... CAS#:88110-89-8 Valganciclovir CAS#:175865-59-5 Valganciclovir ... CAS#:134287-58-4 3,9-dihydro-3-(...
CAS#:194154-40-0 CBZ-valganciclovir CAS#:130914-77-1 (2S,2'S)-2-((2-... CAS#:86629-59-6 2-[(2,6-diamino... CAS#:89419-23-8 2-[(2-aminopuri...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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6H-Purin-6-one, 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-

Vitrasert

Gancyclovir

HHEMG

T56 BN DN FN HNJ D1OY1Q1Q GZ IQ

MFCD00870588

Ganciclovir

Cymevene

bwb759u

2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,9-dihydro-6H-purin-6-one

2'-ndg

6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-

DHPG

biolf62

T56 BN DN FVM INJ B1OY1Q1Q HZ

cymevan

Cytovene

1,3-Propanediol, 2-[(2,3-dihydro-6-hydroxy-2-imino-9H-purin-9-yl)methoxy]-

2-Amino-9-{[(1,3-dihydroxy-2-propanyl)oxy]methyl}-1,9-dihydro-6H-purin-6-one

BW B759U

bw-759u

GVC

2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one

2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one

2-[(6-Hydroxy-2-imino-2,3-dihydro-9H-purin-9-yl)methoxy]-1,3-propanediol

bw-759

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China
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China
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