Valganciclovir Hydrochloride

Modify Date: 2025-08-23 12:56:01

Valganciclovir Hydrochloride Structure
Valganciclovir Hydrochloride structure
 Common Name Valganciclovir Hydrochloride
CAS Number 175865-59-5 Molecular Weight 390.823
Density N/A Boiling Point 629.1ºC at 760 mmHg
Molecular Formula C14H23ClN6O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Valganciclovir Hydrochloride


Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.IC50 Value: Target: CMVin vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases [1].in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease [2]. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) [3].

 Names

Name Valganciclovir hydrochloride
Synonym More Synonyms

 Valganciclovir Hydrochloride Biological Activity

Description Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.IC50 Value: Target: CMVin vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases [1].in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease [2]. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) [3].
Related Catalog
References

[1]. Sugawara M, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9.

[2]. Chawla JS, et al. Oral valganciclovir versus ganciclovir as delayed pre-emptive therapy for patients after allogeneic hematopoietic stem cell transplant: a pilot trial (04-0274) and review of the literature. Transpl Infect Dis. 2012 Jun;14(3):259-67.

[3]. O'Brien S, et al. Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy. Blood. 2008 Feb 15;111(4):1816-9.

 Chemical & Physical Properties

Boiling Point 629.1ºC at 760 mmHg
Molecular Formula C14H23ClN6O5
Molecular Weight 390.823
Exact Mass 390.141846
PSA 171.37000
LogP 0.64680
Vapour Pressure 1.08E-16mmHg at 25°C
Storage condition -20°C

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Synthetic Route

 Synonyms

(2S)-2-amino-3-méthylbutanoate de 2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)méthoxy]-3-hydroxypropyle chlorhydrate
L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
L-valine, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride
2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate hydrochloride
2-[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl-(2S)-2-amino-3-methylbutanoathydrochlorid
Valganciclovir Hydrochloride
Valganciclovir HCl
2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate hydrochloride (1:1)
L-Valine, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
2-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate hydrochloride
L-Valine (2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester
Valganciclovir (hydrochloride)
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Valganciclovir Hydrochloride suppliers

Price: $145/10mM*1mLinDMSO

Reference only. check more Valganciclovir Hydrochloride price

Related Compounds: More...
D-Valganciclovir Hydrochloride
1393911-57-3
Valganciclovir hydrochloride,(S)
175865-61-9
Valganciclovir hydrochloride,(R)
175865-67-5
N-Methyl Valganciclovir Hydrochloride
1401562-16-0
Valganciclovir-d8 hydrochloride
1132088-63-1
carnitine hydrochloride
56-99-5
Triprolidine hydrochloride
6138-79-0
bucumolol hydrochloride
36625-96-4
Branaplam hydrochloride
1562338-39-9
4-Chloro-5-hydroxy-2-methylpyridine
1261811-68-0
Arabinooctaose
190852-28-9
2',6'-Difluoro-3'-methoxyphenacyl chloride
929249-87-6
Methyl 6-amino-5-(3-ethoxy-3-oxo-1-propen-1-yl)-4-pyrimidinecarboxylate
893444-12-7
(5-Chloro-6-methylpyridin-3-YL)methanamine
1256819-08-5
3-(3,5-Dimethoxy-4-methylphenyl)propanenitrile
2113499-33-3
7-[(2,4-dichlorophenyl)methyl]-8-hydrazinyl-1,3-dimethyl-5H-purin-7-ium-2,6-dione
949438-74-8
3-Amino-4-methoxybut-2-enenitrile
168686-01-9
4-Methoxy-3-[[[5-methyl-2-(1-piperidinyl)phenyl]amino]sulfonyl]benzoic acid
2408837-76-1
3-[[[5-Fluoro-2-(1-piperidinyl)phenyl]amino]sulfonyl]-4-methoxybenzoic acid
2408831-56-9
Chemsrc provides Valganciclovir Hydrochloride(CAS#:175865-59-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Valganciclovir Hydrochloride are included as well.>> amp version: Valganciclovir Hydrochloride

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved