2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸
2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸结构式
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常用名 | 2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸 | 英文名 | 4'-Hydroxy diclofenac |
|---|---|---|---|---|
| CAS号 | 64118-84-9 | 分子量 | 312.148 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 432.7±45.0 °C at 760 mmHg | |
| 分子式 | C14H11Cl2NO3 | 熔点 | 178-185ºC dec. | |
| MSDS | 中文版 美版 | 闪点 | 215.5±28.7 °C | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase.
Pharmacogenomics J. 14(4) , 343-9, (2014) Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and diclofenac. We have recently reported a new allelic variant, CYP2C9*35, found in a warfarin hypersensitive patient with Arg125Leu and Arg144Cys mutations. Here, we... |
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Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice.
Toxicol. In Vitro 29 , 1569-76, (2015) Licochalcone A (LCA) is a major bioactive compound in traditional Chinese herbal liquorice that possesses multiple pharmacological activities. However, the effects of the potential herb-drug interactions (HDIs) between LCA and therapeutic drugs on the inhibit... |
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Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase.
Appl. Microbiol. Biotechnol. 99(7) , 3081-91, (2015) Diclofenac is a nonsteroidal anti-inflammatory drug. It undergoes hydroxylation by mammalian cytochrome P450 enzymes at 4'- and/or 5'-positions. A bacterial P450 enzyme, CYP105D7 from Streptomyces avermitilis, has been shown to catalyze hydroxylation of 1-deo... |