4'-Hydroxy diclofenac

4'-Hydroxy diclofenac Structure
4'-Hydroxy diclofenac structure
Common Name 4'-Hydroxy diclofenac
CAS Number 64118-84-9 Molecular Weight 312.148
Density 1.5±0.1 g/cm3 Boiling Point 432.7±45.0 °C at 760 mmHg
Molecular Formula C14H11Cl2NO3 Melting Point 178-185ºC dec.
MSDS Chinese USA Flash Point 215.5±28.7 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase.

Pharmacogenomics J. 14(4) , 343-9, (2014)

Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and diclofenac. We have recently reported a new allelic variant, CYP2C9*35, found in a warfarin hypersensitive patient with Arg125Leu and Arg144Cys mutations. Here, we...

Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice.

Toxicol. In Vitro 29 , 1569-76, (2015)

Licochalcone A (LCA) is a major bioactive compound in traditional Chinese herbal liquorice that possesses multiple pharmacological activities. However, the effects of the potential herb-drug interactions (HDIs) between LCA and therapeutic drugs on the inhibit...

Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase.

Appl. Microbiol. Biotechnol. 99(7) , 3081-91, (2015)

Diclofenac is a nonsteroidal anti-inflammatory drug. It undergoes hydroxylation by mammalian cytochrome P450 enzymes at 4'- and/or 5'-positions. A bacterial P450 enzyme, CYP105D7 from Streptomyces avermitilis, has been shown to catalyze hydroxylation of 1-deo...