![]() 4'-Hydroxy diclofenac structure
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Common Name | 4'-Hydroxy diclofenac | ||
---|---|---|---|---|
CAS Number | 64118-84-9 | Molecular Weight | 312.148 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 432.7±45.0 °C at 760 mmHg | |
Molecular Formula | C14H11Cl2NO3 | Melting Point | 178-185ºC dec. | |
MSDS | Chinese USA | Flash Point | 215.5±28.7 °C | |
Symbol |
![]() ![]() GHS02, GHS07 |
Signal Word | Danger |
High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase.
Pharmacogenomics J. 14(4) , 343-9, (2014) Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and diclofenac. We have recently reported a new allelic variant, CYP2C9*35, found in a warfarin hypersensitive patient with Arg125Leu and Arg144Cys mutations. Here, we... |
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Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice.
Toxicol. In Vitro 29 , 1569-76, (2015) Licochalcone A (LCA) is a major bioactive compound in traditional Chinese herbal liquorice that possesses multiple pharmacological activities. However, the effects of the potential herb-drug interactions (HDIs) between LCA and therapeutic drugs on the inhibit... |
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Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase.
Appl. Microbiol. Biotechnol. 99(7) , 3081-91, (2015) Diclofenac is a nonsteroidal anti-inflammatory drug. It undergoes hydroxylation by mammalian cytochrome P450 enzymes at 4'- and/or 5'-positions. A bacterial P450 enzyme, CYP105D7 from Streptomyces avermitilis, has been shown to catalyze hydroxylation of 1-deo... |
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