异绒白乳菇醛
异绒白乳菇醛结构式
|
常用名 | 异绒白乳菇醛 | 英文名 | Cycloprop[e]indene-1a,2(1H)-dicarboxaldehyde,3a,4,5,6,6a,6b-hexahydro-5,5,6b-trimethyl-, (1aS,3aS,6aS,6bR)- |
|---|---|---|---|---|
| CAS号 | 37841-91-1 | 分子量 | 232.31800 | |
| 密度 | 1.211g/cm3 | 沸点 | 322.8ºC at 760mmHg | |
| 分子式 | C15H20O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 120.9ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety.
Br. J. Pharmacol. 119 , 283-290, (1996) 1. The irritant fungal terpenoid isovelleral caused protective eye-wiping movements in the rat upon intraocular instillation and showed cross-tachyphylaxis with capsaicin, the pungent principle in hot pepper. 2. Isovelleral induced a dose-dependent calcium up... |
|
|
Structure-activity relationships for unsaturated dialdehydes. 10. The generation of bioactive products by autoxidation of isovelleral and merulidial.
Acta Chem. Scand. 49(7) , 530-5, (1995) The autoxidation of the two mutagenic and antimicrobial sesquiterpenes merulidial (1a) and isovelleral (5) generates a number of bioactive products that are suggested to be partly responsible for the mutagenic and antimicrobial activities of the two compounds... |
|
|
Sesquiterpenoid unsaturated dialdehydes increase the concentration of intracellular free Ca2+ in human neuroblastoma SH-SY5Y cells.
Nat. Toxins 2(2) , 89-95, (1994) The effect of the three sesquiterpenoid unsaturated dialdehydes--polygodial, isovelleral, and epipolygodial--on intracellular free Ca2+ concentration, [Ca2+]i, was investigated in the human neuroblastoma cell line SH-SY5Y. [Ca2+]i was measured by the Fura-2 s... |
|
|
The preparation and bioactivities of (-)-isovelleral.
Bioorg. Med. Chem. 5(7) , 1363-7, (1997) The resolution of synthetic (+/-)-isovelleral (1), via chromatographic separation of the two diastereomers of the (-)-menthoxyacetic acid diester of the corresponding (+/-)-diol (3), yielded both enantiomers of the bioactive fungal metabolite (+)-isovelleral ... |
|
|
A novel route to the marasmane skeleton via a tandem rearrangement-cyclopropanation reaction. total synthesis of (+)-isovelleral.
J. Org. Chem. 66(7) , 2350-7, (2001) A general and efficient route to the marasmane skeleton is described. Total syntheses of two simple marasmanes (35 and 37) in racemic form were achieved using a MgI2-catalyzed rearrangement-cyclopropanation reaction of trimethylsilyl enol ether 31 derived fro... |
|
|
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology.
Br. J. Pharmacol. 130(4) , 916-22, (2000) The vanilloid receptor (VR1) is a ligand-gated ion channel, which plays an important role in nociceptive processing. Therefore, a pharmacological characterization of the recently cloned rat VR1 (rVR1) was undertaken. HEK293 cells stable expressing rVR1 (rVR1-... |
|
|
Tridemethylisovelleral, a potent cytotoxic agent.
Bioorg. Med. Chem. 13(22) , 6145-50, (2005) The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system but lacking the three me... |
|
|
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.
Eur. J. Pharmacol. 417(1-2) , 51-8, (2001) A full pharmacological characterisation of the recently cloned human vanilloid VR1 receptor was undertaken. In whole-cell patch clamp studies, capsaicin (10 microM) elicited a slowly activating/deactivating inward current in human embryonic kidney (HEK293) ce... |
|
|
Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors.
Biochem. Pharmacol. 65(1) , 143-51, (2003) This study compared the actions of members of five different chemical classes of vanilloid agonists at the recombinant rat vanilloid VR1 receptor expressed in HEK293 cells, and at endogenous vanilloid receptors on dorsal root ganglion cells and sensory nerves... |
|
|
Polygodial induces inositol phosphate turnover in human neuroblastoma SH-SY5Y cells.
Neurosci. Lett. 217(1) , 50-4, (1996) The pungent sesquiterpenoid unsaturated dialdehydes polygodial and isovelleral, have previously been shown to increase the intracellular free calcium concentration [Ca2+]i in human neuroblastoma SH-SY5Y cells, partly by a release from intracellular Ca2+ store... |