阿西莫司
阿西莫司结构式
|
常用名 | 阿西莫司 | 英文名 | Acipimox |
|---|---|---|---|---|
| CAS号 | 51037-30-0 | 分子量 | 154.123 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 539.0±45.0 °C at 760 mmHg | |
| 分子式 | C6H6N2O3 | 熔点 | 177-180 °C | |
| MSDS | 中文版 美版 | 闪点 | 279.8±28.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
Kinetics and utilization of lipid sources during acute exercise and acipimox.
Am. J. Physiol. Endocrinol. Metab. 307(2) , E199-208, (2014) Overweight is associated with abnormalities of lipid metabolism, many of which are reversed by exercise. We investigated the impact of experimental antilipolysis and acute exercise on lipid kinetics and oxidation from VLDL-TG, plasma FFA, and "residual lipids... |
|
|
The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.
Am. J. Physiol. Endocrinol. Metab. 295(2) , E413-9, (2008) Lipolysis may regulate liver free fatty acid (FFA) uptake and triglyceride accumulation; both are potential causes of insulin resistance and liver damage. We evaluated whether 1) systemic FFA release is the major determinant of liver FFA uptake in fasting hum... |
|
|
ECG-triggered 18F-fluorodeoxyglucose positron emission tomography imaging of the rat heart is dramatically enhanced by acipimox.
Eur. J. Nucl. Med. Mol. Imaging 37(9) , 1745-50, (2010) 18F-Fluorodeoxyglucose (FDG) imaging, provided by current positron emission tomography (PET) systems dedicated to small animals,might provide a precise functional assessment of the left ventricle (LV) in rats, although conventional metabolic conditioning by h... |
|
|
Effects of acute and one-week fatty acid lowering on cardiac function and insulin sensitivity in relation with myocardial and muscle fat and adiponectin levels.
J. Clin. Endocrinol. Metab. 97(9) , 3277-84, (2012) We tested the hypothesis that a persistent reduction in free fatty acid (FFA) levels improves cardiac function and systemic insulin sensitivity via a reduction in the myocardial and skeletal muscle adiposities and a modulation in adipokine release.Study subje... |
|
|
The diagnosis of GH deficiency in obese patients: a reappraisal with GHRH plus arginine testing after pharmacological blockade of lipolysis.
Eur. J. Endocrinol. 163(2) , 201-6, (2010) The diagnosis of GH deficiency (GHD) in obese patients is complicated by the reduced GH secretion associated with overweight. A GH response to GHRH+arginine lower than 4.2 microg/l is currently considered indicative of GHD in obesity. The aim of the study was... |
|
|
Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates.
Clin. Sci. 121(4) , 169-77, (2011) Suppression of lipolysis by acipimox is known to improve insulin-stimulated glucose disposal, and this is an important phenomenon. The mechanism has been assumed to be an enhancement of glucose storage as glycogen, but no direct measurement has tested this co... |
|
|
Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects.
Am. J. Physiol. Endocrinol. Metab. 296(3) , E454-61, (2009) Normal beta-cells adjust their function to compensate for any decrease in insulin sensitivity. Our aim was to explore whether a prolonged fast would allow a study of the effects of changes in circulating free fatty acid (FFA) levels on insulin secretion and i... |
|
|
Acipimox-enhanced ¹⁸F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model.
Int. J. Cardiovasc. Imaging 28(6) , 1407-15, (2012) The rat myocardial infarction (MI) model is widely used to study left ventricular (LV) remodeling. In this study, acipimox-enhanced (18)F-Fluorodeoxyglucose (FDG) gated-positron emission tomography (PET) was assessed for characterizing and predicting early re... |
|
|
Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes.
J. Clin. Endocrinol. Metab. 94(9) , 3297-305, (2009) Because GH stimulates lipolysis, an increase in circulating free fatty acid levels, as opposed to a direct effect of high GH levels, could underlie the development of insulin resistance in type 1 diabetes (T1D). Our aim was to explore the relative contributio... |
|
|
Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.
Arterioscler. Thromb. Vasc. Biol. 29(12) , 2028-32, (2009) The advent of HIV protease inhibitors has greatly extended the life span of AIDS patients. With an aging HIV(+) population, the cardiometabolic side effects of these drugs are becoming increasingly important clinical concerns. The purpose of this study was to... |