Acipimox

Modify Date: 2024-01-03 13:49:51

Acipimox structure	Common Name	Acipimox
	CAS Number	51037-30-0	Molecular Weight	154.123
	Density	1.4±0.1 g/cm3	Boiling Point	539.0±45.0 °C at 760 mmHg
	Molecular Formula	C₆H₆N₂O₃	Melting Point	177-180 °C
	MSDS	Chinese USA	Flash Point	279.8±28.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Acipimox

Acipimox is a niacin derivative used as a hypolipidemic agent.Target: Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout. From Wikipedia.

Name	5-methyl-4-oxidopyrazin-4-ium-2-carboxylic acid
Synonym	More Synonyms

Description	Acipimox is a niacin derivative used as a hypolipidemic agent.Target: Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout. From Wikipedia.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cardiovascular Disease
References	[1]. http://en.wikipedia.org/wiki/Acipimox

Density	1.4±0.1 g/cm3
Boiling Point	539.0±45.0 °C at 760 mmHg
Melting Point	177-180 °C
Molecular Formula	C₆H₆N₂O₃
Molecular Weight	154.123
Flash Point	279.8±28.7 °C
Exact Mass	154.037842
PSA	75.65000
LogP	-1.38
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.608
Storage condition	2-8°C

Acipimox MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ2453000

CHEMICAL NAME :: 2-Pyrazinecarboxylic acid, 5-methyl-, 4-oxide

CAS REGISTRY NUMBER :: 51037-30-0

BEILSTEIN REFERENCE NO. :: 0777471

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H6-N2-O3

MOLECULAR WEIGHT :: 154.14

WISWESSER LINE NOTATION :: T6N DNJ AO B1 EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 15,157,1980

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36
Safety Phrases	S26
RIDADR	NONH for all modes of transport
RTECS	UQ2453000
HS Code	2942000000

N/A

CAS#:51037-35-5

Acipimox

CAS#:51037-30-0

Literature: Carlo Erba S.p.A. Patent: US4002750 A1, 1977 ;

Maleic anhydride

CAS#:108-31-6

5-Methyl-2-pyra...

CAS#:5521-55-1

Acipimox

CAS#:51037-30-0

Literature: Carlo Erba S.p.A. Patent: US4002750 A1, 1977 ;

5-Methyl-2-pyra...

CAS#:5521-55-1

Hydrogen peroxide

CAS#:7722-84-1

Acipimox

CAS#:51037-30-0

Literature: Montedison S.p.A. Patent: US4866178 A1, 1989 ;

5-methyl-4-oxid...

CAS#:51037-25-3

Acipimox

CAS#:51037-30-0

Literature: Ambrogi; Cozzi; Sanjust; et al. European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 157 - 163

5-Methyl-2-pyra...

CAS#:5521-57-3

Acipimox

CAS#:51037-30-0

Literature: Ambrogi; Cozzi; Sanjust; et al. European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 157 - 163

Precursor 5
CAS#:108-31-6 Maleic anhydride CAS#:5521-55-1 5-Methyl-2-pyra... CAS#:7722-84-1 Hydrogen peroxide CAS#:51037-25-3 5-methyl-4-oxid...
CAS#:5521-57-3 5-Methyl-2-pyra...
DownStream 2
CAS#:74416-38-9 methyl 5-methyl... CAS#:83056-59-1 2-Methoxymethyl...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Kinetics and utilization of lipid sources during acute exercise and acipimox.

Am. J. Physiol. Endocrinol. Metab. 307(2) , E199-208, (2014)

Overweight is associated with abnormalities of lipid metabolism, many of which are reversed by exercise. We investigated the impact of experimental antilipolysis and acute exercise on lipid kinetics a...

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.

Am. J. Physiol. Endocrinol. Metab. 295(2) , E413-9, (2008)

Lipolysis may regulate liver free fatty acid (FFA) uptake and triglyceride accumulation; both are potential causes of insulin resistance and liver damage. We evaluated whether 1) systemic FFA release ...

ECG-triggered 18F-fluorodeoxyglucose positron emission tomography imaging of the rat heart is dramatically enhanced by acipimox.

Eur. J. Nucl. Med. Mol. Imaging 37(9) , 1745-50, (2010)

18F-Fluorodeoxyglucose (FDG) imaging, provided by current positron emission tomography (PET) systems dedicated to small animals,might provide a precise functional assessment of the left ventricle (LV)...

5-methyl-2-pyrazinoic-4-oxide

2-Pyrazinecarboxylic acid, 5-methyl-, 4-oxide

2-Carboxy-5-methylpyrazine 4-oxide,5-Methylpyrazinecarboxylic acid 4-oxide

5-Carboxy-2-methylpyrazine 1-oxide

5-methyl-4-oxy-pyrazine-2-carboxylic acid

5-methylpyrazine-2-carboxylic acid 4-oxide

2-carboxy-5-methylpyrazine 4-oxide

Acipimox

K-9321

Olbetam

5-Methylpyrazinecarboxylic acid 4-oxide

5-Methyl-2-pyrazinecarboxylic acid 4-oxide

2-methyl-5-pyrazinecarboxylic acid 1-oxide

Olbemox

EINECS 256-928-3

T6N DNJ AO B1 EVQ

MFCD00865757

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Acipimox
Price: ￥1818.0/5g ￥598.0/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Acipimox
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Acipimox
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: $94/10mM*1mLinDMSO

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Acipimox

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