碘克沙醇
碘克沙醇结构式
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常用名 | 碘克沙醇 | 英文名 | Iodixanol |
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| CAS号 | 92339-11-2 | 分子量 | 1550.182 | |
| 密度 | 2.3±0.1 g/cm3 | 沸点 | 1250.9±65.0 °C at 760 mmHg | |
| 分子式 | C35H44I6N6O15 | 熔点 | 262-267ºC (dec.) | |
| MSDS | N/A | 闪点 | 710.3±34.3 °C |
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Inhibition of CD40-induced N-Ras activation reduces leishmania major infection.
J. Immunol. 194(8) , 3852-60, (2015) Leishmania major is a parasite that resides and replicates in macrophages. We previously showed that the parasite enhanced CD40-induced Raf-MEK-ERK signaling but inhibited PI3K-MKK-p38MAPK signaling to proleishmanial effects. As Raf and PI3K have a Ras-bindin... |
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CD40 is required for protective immunity against liver stage Plasmodium infection.
J. Immunol. 194(5) , 2268-79, (2015) The costimulatory molecule CD40 enhances immunity through several distinct roles in T cell activation and T cell interaction with other immune cells. In a mouse model of immunity to liver stage Plasmodium infection, CD40 was critical for the full maturation o... |
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Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells.
FASEB J. 28(12) , 5122-35, (2014) Lon is a nuclear-encoded, mitochondrial protease that assists protein folding, degrades oxidized/damaged proteins, and participates in maintaining mtDNA levels. Here we show that Lon is up-regulated in several human cancers and that its silencing in RKO colon... |
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Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.
Virology 458-459 , 190-208, (2014) Recently, cell culture systems producing hepatitis C virus particles (HCVcc) were developed. Establishment of serum-free culture conditions is expected to facilitate development of a whole-virus inactivated HCV vaccine. We describe generation of genotype 1-6 ... |
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RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.
Biochem. Biophys. Res. Commun. 454(1) , 19-24, (2015) Hepatitis C virus (HCV) is a positive-strand RNA virus responsible for chronic liver disease and hepatocellular carcinoma (HCC). RacGTPase-activating protein 1 (RacGAP1) plays an important role during GTP hydrolysis to GDP in Rac1 and CDC42 protein and has be... |
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Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.
J. Virol. 88(22) , 13221-30, (2014) Human coronavirus NL63 (HCoV-NL63) is an alphacoronavirus that was first identified in 2004 in the nasopharyngeal aspirate from a 7-month-old patient with a respiratory tract infection. Previous studies showed that HCoV-NL63 and the genetically distant severe... |
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N-glycosylation profiling of porcine reproductive and respiratory syndrome virus envelope glycoprotein 5.
Virology 478 , 86-98, (2015) Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-sense ssRNA virus whose envelope contains four glycoproteins and three nonglycosylated proteins. Glycans of major envelope glycoprotein 5 (GP5) are proposed as important for virus assem... |
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Functional analysis of porcine reproductive and respiratory syndrome virus N-glycans in infection of permissive cells.
Virology 477 , 82-8, (2015) The role of envelope protein-linked N-glycans in porcine reproductive and respiratory syndrome virus (PRRSV) infection of permissive cells was examined. N-acetylglucosamine (GlcNAc) and N-acetyllactosamine (LacNAc) oligomer-specific lectins bound to PRRSV and... |
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Egr-1 activation by cancer-derived extracellular vesicles promotes endothelial cell migration via ERK1/2 and JNK signaling pathways.
PLoS ONE 9(12) , e115170, (2014) Various mammalian cells, including cancer cells, shed extracellular vesicles (EVs), also known as exosomes and microvesicles, into surrounding tissues. These EVs play roles in tumor growth and metastasis by promoting angiogenesis. However, the detailed mechan... |
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Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.
PLoS ONE 10(3) , e0118273, (2015) Calcium dysregulation is causally linked with various forms of neuropathology including seizure disorders, multiple sclerosis, Huntington's disease, Alzheimer's, spinal cerebellar ataxia (SCA) and chronic pain. Carbonic anhydrase-8 (Car8) is an allosteric inh... |