Iodixanol

Modify Date: 2024-01-04 13:51:52

Iodixanol structure	Common Name	Iodixanol
	CAS Number	92339-11-2	Molecular Weight	1550.182
	Density	2.3±0.1 g/cm3	Boiling Point	1250.9±65.0 °C at 760 mmHg
	Molecular Formula	C₃₅H₄₄I₆N₆O₁₅	Melting Point	262-267ºC (dec.)
	MSDS	N/A	Flash Point	710.3±34.3 °C

Use of Iodixanol

Iodixanol is an iodine-containing non-ionic radiocontrast agent[1].

Name	iodixanol
Synonym	More Synonyms

Description	Iodixanol is an iodine-containing non-ionic radiocontrast agent[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	Iodixanol exhibits less kidney toxicity[1].
References	[1]. Iodixanol.

Density	2.3±0.1 g/cm3
Boiling Point	1250.9±65.0 °C at 760 mmHg
Melting Point	262-267ºC (dec.)
Molecular Formula	C₃₅H₄₄I₆N₆O₁₅
Molecular Weight	1550.182
Flash Point	710.3±34.3 °C
Exact Mass	1549.713257
PSA	339.09000
LogP	-5.88
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.752
Storage condition	Refrigerator
Water Solubility	Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ3075000

CHEMICAL NAME :: 1,3-Benzenedicarboxamide, 5,5'-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis (N,N'- bis(2,3-dihydroxypropyl)-2,4,6-triiodo-

CAS REGISTRY NUMBER :: 92339-11-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >42757 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - hemorrhage

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30512 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 73228 mg/kg/3W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 54921 mg/kg/3W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995

RIDADR	NONH for all modes of transport
HS Code	2924299090

2-(1,3-dichloro...

CAS#:28659-12-3

Iohexol Intermediate

CAS#:31127-80-7

Iodixanol

CAS#:92339-11-2

Literature: US7696381 B1, ; Page/Page column 4 ;

Iohexol Intermediate

CAS#:31127-80-7

Epichlorohydrin

CAS#:106-89-8

~68%

Iodixanol

CAS#:92339-11-2

Literature: HOVIONE CHINA HOLDING LIMITED; HU, Zhiqi; ZHANG, Huoying Patent: WO2011/63551 A1, 2011 ; Location in patent: Page/Page column 18 ;

Iohexol Intermediate

CAS#:31127-80-7

Epichlorohydrin

CAS#:106-89-8

~84%

Iohexol

CAS#:66108-95-0

Iodixanol

CAS#:92339-11-2

Literature: WO2011/63551 A1, ; Page/Page column 15-16 ;

1,3-Dichloro-2-...

CAS#:96-23-1

Iohexol Intermediate

CAS#:31127-80-7

Iodixanol

CAS#:92339-11-2

Literature: US7696381 B1, ; Page/Page column 4 ;

Iohexol Intermediate

CAS#:31127-80-7

Iohexol

CAS#:66108-95-0

Iodixanol

CAS#:92339-11-2

Literature: US2011/21829 A1, ; Page/Page column 5 ;

Precursor 4
CAS#:28659-12-3 2-(1,3-dichloro... CAS#:31127-80-7 Iohexol Intermediate CAS#:106-89-8 Epichlorohydrin CAS#:96-23-1 1,3-Dichloro-2-...
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Inhibition of CD40-induced N-Ras activation reduces leishmania major infection.

J. Immunol. 194(8) , 3852-60, (2015)

Leishmania major is a parasite that resides and replicates in macrophages. We previously showed that the parasite enhanced CD40-induced Raf-MEK-ERK signaling but inhibited PI3K-MKK-p38MAPK signaling t...

CD40 is required for protective immunity against liver stage Plasmodium infection.

J. Immunol. 194(5) , 2268-79, (2015)

The costimulatory molecule CD40 enhances immunity through several distinct roles in T cell activation and T cell interaction with other immune cells. In a mouse model of immunity to liver stage Plasmo...

Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells.

FASEB J. 28(12) , 5122-35, (2014)

Lon is a nuclear-encoded, mitochondrial protease that assists protein folding, degrades oxidized/damaged proteins, and participates in maintaining mtDNA levels. Here we show that Lon is up-regulated i...

1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-

5,5'-[(2-Hydroxypropane-1,3-diyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide]

Q1YQ1MVR BI DI FI CVM1YQ1Q ENV1&1YQ1NV1&R BI DI FI CVM1YQ1Q EVM1YQ1Q

1,3-bis(acetylamino)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane

Iodixanolum [Latin]

Visipaque

Indixanol

3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide

visipaqueTM

1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-

5-[acetyl-[3-[N-acetyl-3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide

Iodixanolum

Visipaque 270

3,3',5',5'-tetrakis(2,3-dixydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide

UNII-HW8W27HTXX

5,5'-[(2-Hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide]

Iodixanol

Visipaque 320

DC Chemicals Limited
China
Product Name: Iodixanol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: iodixanol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥1100/10 mM * 1 mL in DMSO

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Iodixanol

Use of Iodixanol

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Iodixanol Biological Activity

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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