92339-11-2

• 常用中文名：碘克沙醇
• 常用英文名：Iodixanol
• CAS号：92339-11-2
• 分子式：C₃₅H₄₄I₆N₆O₁₅
• 分子量：1550.182
• 相关类别： 原料药 诊断用药 影象检查用药
• 发布时间：2018-03-29 08:00:00
• 更新时间：2025-08-22 18:55:21
• 【用途1】
  非离子型X-光照影剂。
  【用途2】
  X－线造影剂。用于成人的心血管造影、脑血管造影(常规的与i.a. DSA)、外周动脉造影(常规的与i.a. DSA)、腹部血管造影(i.a. DSA)、尿路造影、静脉造影以及CT－增强检查。

名称

• 中文名: 碘克沙醇
• 英文名: iodixanol
• 中文别名: 5,5'-((2-羟基-1,3-丙烷)双(乙酰亚氨))双(N,N'-二(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺; 碘海醇; 1,3-双(乙酰胺基)-N,N'-双[3,5-双(2,3-二羟丙基氨羰基)-2,4,6-三碘苯基]-2-羟基丙烷
• 英文别名: 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-; 5,5'-[(2-Hydroxypropane-1,3-diyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide]; Q1YQ1MVR BI DI FI CVM1YQ1Q ENV1&1YQ1NV1&R BI DI FI CVM1YQ1Q EVM1YQ1Q; 1,3-bis(acetylamino)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane; Iodixanolum [Latin]; Visipaque; Indixanol; 3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide; visipaqueTM; 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-; 5-[acetyl-[3-[N-acetyl-3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; Iodixanolum; Visipaque 270; 3,3',5',5'-tetrakis(2,3-dixydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide; UNII-HW8W27HTXX; 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide]; Iodixanol; Visipaque 320

物化性质

• 密度: 2.3±0.1 g/cm3
• 沸点: 1250.9±65.0 °C at 760 mmHg
• 熔点: 262-267ºC (dec.)
• 分子式: C₃₅H₄₄I₆N₆O₁₅
• 分子量: 1550.182
• 闪点: 710.3±34.3 °C
• 精确质量: 1549.713257
• PSA: 339.09000
• LogP: -5.88
• 外观性状: 灰白色至白色粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.752
• 储存条件: Refrigerator
• 水溶解性: Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.

生物活性

• 描述: Iodixanol 是一种含碘的非离子放射性造影剂。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体内研究: 碘xanol表现出较少的肾毒性[1]。
• 参考文献:

  [1]. Iodixanol.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CZ3075000 CHEMICAL NAME : 1,3-Benzenedicarboxamide, 5,5'-((2-hydroxy-1,3-propanediyl)bis(acetylimino))bis (N,N'- bis(2,3-dihydroxypropyl)-2,4,6-triiodo- CAS REGISTRY NUMBER : 92339-11-2 LAST UPDATED : 199806 DATA ITEMS CITED : 4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >42757 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - hemorrhage REFERENCE : ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30512 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 73228 mg/kg/3W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 54921 mg/kg/3W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 399,69,1995

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2924299090

合成路线

28659-12-3 31127-80-7 ~% 92339-11-2

文献：US7696381 B1, ; Page/Page column 4 ;

31127-80-7 106-89-8 ~68% 92339-11-2

文献：HOVIONE CHINA HOLDING LIMITED; HU, Zhiqi; ZHANG, Huoying Patent: WO2011/63551 A1, 2011 ; Location in patent: Page/Page column 18 ;

31127-80-7 106-89-8 ~84% 66108-95-0 92339-11-2

文献：WO2011/63551 A1, ; Page/Page column 15-16 ;

96-23-1 31127-80-7 ~% 92339-11-2

文献：US7696381 B1, ; Page/Page column 4 ;

31127-80-7 ~% 66108-95-0 92339-11-2

文献：US2011/21829 A1, ; Page/Page column 5 ;

上下游产品

上游产品  4
28659-12-3 31127-80-7 106-89-8 96-23-1
下游产品  0

制备

【方法1】
化合物(Ⅰ)和1，3-二氯-2-丙醇缩合，即得碘克沙醇。

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%