DBCO-PEG1-NHS ester

Modify Date: 2024-01-12 14:16:17

DBCO-PEG1-NHS ester Structure
DBCO-PEG1-NHS ester structure
Common Name DBCO-PEG1-NHS ester
CAS Number 2228857-34-7 Molecular Weight 517.53
Density N/A Boiling Point N/A
Molecular Formula C28H27N3O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DBCO-PEG1-NHS ester


DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name DBCO-PEG1-NHS ester
Synonym More Synonyms

 DBCO-PEG1-NHS ester Biological Activity

Description DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C28H27N3O7
Molecular Weight 517.53

 Synonyms

MFCD31615436