Azido-PEG1-NHS ester

Modify Date: 2024-01-12 08:15:42

Azido-PEG1-NHS ester Structure
Azido-PEG1-NHS ester structure
Common Name Azido-PEG1-NHS ester
CAS Number 1807530-06-8 Molecular Weight 256.215
Density N/A Boiling Point N/A
Molecular Formula C9H12N4O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azido-PEG1-NHS ester


Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Azido-PEG1-NHS ester
Synonym More Synonyms

 Azido-PEG1-NHS ester Biological Activity

Description Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C9H12N4O5
Molecular Weight 256.215
Exact Mass 256.080780
LogP -1.51

 Synonyms

1-{[3-(2-Azidoethoxy)propanoyl]oxy}-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[3-(2-azidoethoxy)-1-oxopropoxy]-
MFCD26793773
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