Azido-PEG1-NHS ester

Names

[ Name ]:
Azido-PEG1-NHS ester

[Synonym ]:
1-{[3-(2-Azidoethoxy)propanoyl]oxy}-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[3-(2-azidoethoxy)-1-oxopropoxy]-
MFCD26793773

Biological Activity

[Description]:

Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₂N₄O₅

[ Molecular Weight ]:
256.215

[ Exact Mass ]:
256.080780

[ LogP ]:
-1.51

Related Compounds

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