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m-PEG1-NHS ester

Names

[ CAS No. ]:
1027371-75-0

[ Name ]:
m-PEG1-NHS ester

[Synonym ]:
MFCD20229579

Biological Activity

[Description]:

m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C8H11NO5

[ Molecular Weight ]:
201.18

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds