2228857-34-7

2228857-34-7 structure
2228857-34-7 structure
  • Name: DBCO-PEG1-NHS ester
  • Chemical Name: DBCO-PEG1-NHS ester
  • CAS Number: 2228857-34-7
  • Molecular Formula: C28H27N3O7
  • Molecular Weight: 517.53
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2020-06-05 10:03:16
  • Modify Date: 2024-01-12 14:16:17
  • DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name DBCO-PEG1-NHS ester
Synonyms MFCD31615436
Description DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C28H27N3O7
Molecular Weight 517.53