RBP4 inhibitor 1

Modify Date: 2025-08-26 10:45:58

RBP4 inhibitor 1 Structure
RBP4 inhibitor 1 structure
Common Name RBP4 inhibitor 1
CAS Number 1198180-03-8 Molecular Weight 357.25
Density N/A Boiling Point N/A
Molecular Formula C14H13F6NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RBP4 inhibitor 1


RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC50s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice[1].

 Names

Name RBP4 inhibitor 1

 RBP4 inhibitor 1 Biological Activity

Description RBP4 inhibitor 1 (compound 43b) is a potent and orally active retinol-binding protein 4 (RBP4) inhibitor with IC50s of 28 nM and 110 nM for human and mouse RBP4. RBP4 inhibitor 1 has a potent and long-lasting blood RBP4-level-reducing effect in mice[1].
Related Catalog
Target

IC50: 28 nM (human RBP4) and 110 nM (mouse RBP4)[1]

References

[1]. Shinji Nakamura, et al. Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers. Bioorg Med Chem. 2022 Jan 15;54:116553.

 Chemical & Physical Properties

Molecular Formula C14H13F6NO3
Molecular Weight 357.25
InChIKey ISWIGCDQVGGYGK-NSHDSACASA-N
SMILES O=C(O)COC1CCN(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1
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