TC-E 5005
Modify Date: 2025-08-26 10:50:04
TC-E 5005 structure
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Common Name | TC-E 5005 | ||
|---|---|---|---|---|
| CAS Number | 959705-64-7 | Molecular Weight | 270.33000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H18N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TC-E 5005TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate[1]. |
| Name | 2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazin e |
|---|---|
| Synonym | More Synonyms |
| Description | TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate[1]. |
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| Related Catalog | |
| Target |
PDE10A:7.28 nM (IC50) PDE2A:239 nM (IC50) hPDE11A:779 nM (IC50) PDE5A:919 nM (IC50) PDE7B:3100 nM (IC50) PDE3A:3700 nM (IC50) |
| In Vitro | TC-E 5005 (500 nM) inhibits norepinephrine or phenylephrine and EFS (electric field stimulation)-induced contraction of human prostate strips[1]. TC-E 5005 (500 nM) shows amplification of treprostinil-induced relaxations, which were significant from 0.03 to 30 μM treprostinil[1]. |
| References |
| Molecular Formula | C15H18N4O |
|---|---|
| Molecular Weight | 270.33000 |
| Exact Mass | 270.14800 |
| PSA | 52.31000 |
| LogP | 2.85540 |
| InChIKey | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| SMILES | CCCc1nc(C)c2c(C)nc3ccc(OC)nc3n12 |
| TC-E 5005 |