1159996-20-9

1159996-20-9 structure

Name: TC-I 2000
Chemical Name: N-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
CAS Number: 1159996-20-9
Molecular Formula: C₂₃H₁₈F₄N₂O
Molecular Weight: 414.39500
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2017-02-15 22:54:02
Modify Date: 2025-09-12 23:12:57
TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC50<5 μM[1].

Name	N-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
Synonyms	sb 611812

Description	TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC50<5 μM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	TRPM8:<5 μM (IC50)
References	[1]. Norman, et al. Preparation of substituted dihydroisoquinoline derivatives for use as TRP-M8 receptor ligands. World Intellectual Property Organization, WO2009073203 A1. 2009-06-11.