DC Chemicals Limited
China
Product Name: TC-DAPK-6
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: TC-DAPK 6
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

315694-89-4

315694-89-4 structure

315694-89-4 structure

Name: TC-DAPK 6
Chemical Name: (4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
CAS Number: 315694-89-4
Molecular Formula: C₁₇H₁₂N₂O₂
Molecular Weight: 276.289
Catalog: Signaling Pathways Apoptosis DAPK
Create Date: 2016-07-15 07:50:57
Modify Date: 2024-01-12 13:41:19
TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP).

Name	(4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
Synonyms	(4Z)-2-[(E)-2-Phenylvinyl]-4-(3-pyridinylmethylene)-1,3-oxazol-5(4H)-one tc-dapk 6 5(4H)-Oxazolone, 2-[(E)-2-phenylethenyl]-4-(3-pyridinylmethylene)-, (4Z)- cs-1062

Description	TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP).
Related Catalog	Signaling Pathways >> Apoptosis >> DAPK Research Areas >> Cancer
Target	IC50: 69 nM (DAPK1), 225 nM (DAPK3)[1]
In Vitro	TC-DAPK 6 is found to be the most potent Death-associated protein kinase (DAPK) inhibitor with enzyme selectivity. When assayed with 10 μM ATP, the IC50 values for DAPK1 and DAPK3 are 69 and 225 nM, respectively. TC-DAPK 6 also inhibits p70S6K (1 μM < IC50< 10 μM)[1].
Kinase Assay	Kinase assay is performed using the Z’-LYTE kinase assay kit Ser/Thr 13 peptide. The standard reaction for compound screening contained 1 mM peptide substrate, 10 mM ATP, 50 mM HEPES (pH 7.4), 10 mM MgCl2, 0.01% Brij-35, and 0.5% DMSO. Human recombinant DAPK1 is used at a final concentration of 2.6 μg/mL, and recombinant DAPK3 is used at a final concentration 1.5 mg/mL. To test the enzyme selectively of the inhibitors (e.g., TC-DAPK 6), ProfilerPro kits are used in the protocol[1].
References	[1]. Okamoto M, et al. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7.

Density	1.2±0.1 g/cm3
Boiling Point	439.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₂N₂O₂
Molecular Weight	276.289
Flash Point	219.7±31.5 °C
Exact Mass	276.089874
PSA	51.55000
LogP	3.62
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.615
Storage condition	2-8℃

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%