17328-16-4

17328-16-4 structure

Name: TC-E 5003
Chemical Name: 2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]sulfonylphenyl]acetamide
CAS Number: 17328-16-4
Molecular Formula: C₁₆H₁₄Cl₂N₂O₄S
Molecular Weight: 401.26400
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2016-02-22 14:44:08
Modify Date: 2024-01-02 18:27:44
TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling[1][2].

Name	2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]sulfonylphenyl]acetamide
Synonyms	4',4''-sulfonylbis(2-chloroacetanilide)

Description	TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Inflammation/Immunology
References	[1]. Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011;19(12):3717-3731. [2]. Kim E, et al. Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. Int J Mol Sci. 2020;21(9):3058. Published 2020 Apr 26.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPAAA Experimental Parasitology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,88,1967

HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%