TC-E 5003

Modify Date: 2024-01-02 18:27:44

TC-E 5003 structure	Common Name	TC-E 5003
	CAS Number	17328-16-4	Molecular Weight	401.26400
	Density	1.504g/cm3	Boiling Point	704.2ºC at 760 mmHg
	Molecular Formula	C₁₆H₁₄Cl₂N₂O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	379.7ºC

Use of TC-E 5003

TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling[1][2].

Name	2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]sulfonylphenyl]acetamide
Synonym	More Synonyms

Description	TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Inflammation/Immunology
References	[1]. Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011;19(12):3717-3731. [2]. Kim E, et al. Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. Int J Mol Sci. 2020;21(9):3058. Published 2020 Apr 26.

Description

TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling[1][2].

Related Catalog

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Research Areas >> Inflammation/Immunology

References

[1]. Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011;19(12):3717-3731.

[2]. Kim E, et al. Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. Int J Mol Sci. 2020;21(9):3058. Published 2020 Apr 26.

Density	1.504g/cm3
Boiling Point	704.2ºC at 760 mmHg
Molecular Formula	C₁₆H₁₄Cl₂N₂O₄S
Molecular Weight	401.26400
Flash Point	379.7ºC
Exact Mass	400.00500
PSA	100.72000
LogP	4.10080
Vapour Pressure	1.12E-19mmHg at 25°C
Index of Refraction	1.639

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WR3150000

CHEMICAL NAME :: Sulfone, bis((4-chloroacetylamino)phenyl)

CAS REGISTRY NUMBER :: 17328-16-4

BEILSTEIN REFERENCE NO. :: 2180613

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H14-Cl2-N2-O4-S

MOLECULAR WEIGHT :: 401.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPAAA Experimental Parasitology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,88,1967

HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4',4''-sulfonylbis(2-chloroacetanilide)

DC Chemicals Limited
China
Product Name: TC-E 5003
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sulfone, bis((4-chloroacetylamino)phenyl)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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