1257395-14-4

1257395-14-4 structure

Name: TC-E 5006
Chemical Name: 2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid
CAS Number: 1257395-14-4
Molecular Formula: C₂₉H₂₉F₄NO₂
Molecular Weight: 499.54000
Catalog: Research Areas Neurological Disease
Create Date: 2018-03-08 13:33:37
Modify Date: 2024-01-10 18:59:08
(Rac)-BIIB042 (Compound 10) is an modulator of γ-Secretase. (Rac)-BIIB042 reduces Amyloid-β 42 level with an EC50 value of 0.39 µM. (Rac)-BIIB042 can be used for the study of Alzheimer's disease[1].

Name	2-(6-((4-fluorophenyl)(4-methylpiperidin-1-yl)methyl)-4'-(trifluoromethyl)biphenyl-3-yl)propanoic acid

Description	(Rac)-BIIB042 (Compound 10) is an modulator of γ-Secretase. (Rac)-BIIB042 reduces Amyloid-β 42 level with an EC50 value of 0.39 µM. (Rac)-BIIB042 can be used for the study of Alzheimer's disease[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Peng H, et al. Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator. ACS Med Chem Lett. 2011 Aug 5;2(10):786-91.