Conantokin G
Conantokin G structure
|
Common Name | Conantokin G | ||
|---|---|---|---|---|
| CAS Number | 93438-65-4 | Molecular Weight | 2264.19000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C88H138N26O44 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Conantokin GConantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G has neuroprotective properties[1][2]. |
| Name | conantokin g |
|---|---|
| Synonym | More Synonyms |
| Description | Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC50 of 480 nM. Conantokin G has neuroprotective properties[1][2]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C88H138N26O44 |
|---|---|
| Molecular Weight | 2264.19000 |
| Exact Mass | 2262.94000 |
| PSA | 1225.52000 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
|
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.
Curr. Drug Targets. CNS Neurol. Disord. 4(2) , 143-51, (2005) Glutamate is the main excitatory neurotransmitter in the central nervous system and it plays a significant role not only in synaptic transmission but also in acute and chronic neuropathologies includi... |
|
|
The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs.
Epilepsy Res. 59(1) , 13-24, (2004) The N-methyl-D-aspartate (NMDA) receptor-gated ion channel is comprised of at least one NR1 subunit and any of four NR2 subunits (NR2A-D). The NR2 subunit confers different pharmacological and kinetic... |
|
|
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.
Neuropharmacology 57(2) , 127-36, (2009) The conantokins are short, naturally occurring peptides that inhibit ion flow through N-methyl-d-aspartate receptor (NMDAR) channels. One member of this peptide family, conantokin-G (con-G), shows hig... |
| 'SLEEPER PEPTIDE' |
| H-GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2 |
| conotoxin GV |
| M.W. 2264.1 C88H138N26O44 |
| GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2 |
| Conotoxin GV,Sleeper Peptide |