ConantokinG

更新时间：2025-09-18 15:23:11

ConantokinG结构式	常用名	ConantokinG	英文名	Conantokin G
	CAS号	93438-65-4	分子量	2264.19000
	密度	N/A	沸点	N/A
	分子式	C₈₈H₁₃₈N₂₆O₄₄	熔点	N/A
	MSDS	中文版美版	闪点	N/A

ConantokinG用途

Conantokin G 是一种 17 个氨基酸的肽,是一种有效,选择性和竞争性的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。Conantokin G 抑制鼠皮质神经元中 NMDA 诱发的电流,IC50 为 480 nM,具有神经保护作用。

中文名	GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2
英文名	conantokin g
英文别名	更多

描述	Conantokin G 是一种 17 个氨基酸的肽,是一种有效,选择性和竞争性的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。Conantokin G 抑制鼠皮质神经元中 NMDA 诱发的电流,IC50 为 480 nM,具有神经保护作用。
相关类别	信号通路 >> 神经信号通路 >> iGluR 研究领域 >> 神经疾病信号通路 >> 跨膜转运 >> iGluR
参考文献	[1]. S D Donevan, et al. Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol Pharmacol. 2000 Sep;58(3):614-23. [2]. A J Williams, et al. Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J Pharmacol Exp Ther. 2000 Jul;294(1):378-86.

描述

相关类别

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

参考文献

[1]. S D Donevan, et al. Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol Pharmacol. 2000 Sep;58(3):614-23.

[2]. A J Williams, et al. Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J Pharmacol Exp Ther. 2000 Jul;294(1):378-86.

分子式	C₈₈H₁₃₈N₂₆O₄₄
分子量	2264.19000
精确质量	2262.94000
PSA	1225.52000
InChIKey	HTBKFGWATIYCSF-UHFFFAOYSA-N
SMILES	CCC(C)C(NC(=O)C(CC(C)C)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C(=O)O)C(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(N)=O
外观性状	白色冻干的固体
储存条件	-20°C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.

Curr. Drug Targets. CNS Neurol. Disord. 4(2) , 143-51, (2005)

Glutamate is the main excitatory neurotransmitter in the central nervous system and it plays a significant role not only in synaptic transmission but also in acute and chronic neuropathologies includi...

The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs.

Epilepsy Res. 59(1) , 13-24, (2004)

The N-methyl-D-aspartate (NMDA) receptor-gated ion channel is comprised of at least one NR1 subunit and any of four NR2 subunits (NR2A-D). The NR2 subunit confers different pharmacological and kinetic...

The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

Neuropharmacology 57(2) , 127-36, (2009)

The conantokins are short, naturally occurring peptides that inhibit ion flow through N-methyl-d-aspartate receptor (NMDAR) channels. One member of this peptide family, conantokin-G (con-G), shows hig...

'SLEEPER PEPTIDE'

H-GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2

conotoxin GV

M.W. 2264.1 C88H138N26O44

GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2

Conotoxin GV,Sleeper Peptide