conantokin R

• 常用名: conantokin R
• 英文名: conantokin R
• CAS号: 202925-60-8
• 分子量: 3098.35
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₂₇H₂₀₁N₃₅O₄₉S₃
• 熔点: N/A
• 闪点: N/A

conantokin R用途

Conantokin R (Con-R) 是一种 NMDA 受体肽拮抗剂,其 IC50 为 93 nM。Conantokin R 与 Zn2+ 和 Mg2+ 结合的 Kd 分别为 0.15 μM 和 6.5 μM。Conantokin R 显示抗惊厥活性。

conantokin R名称

• 英文名: Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propanyl]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo

conantokin R生物活性

• 描述: Conantokin R (Con-R) 是一种 NMDA 受体肽拮抗剂,其 IC50 为 93 nM。Conantokin R 与 Zn2+ 和 Mg2+ 结合的 Kd 分别为 0.15 μM 和 6.5 μM。Conantokin R 显示抗惊厥活性。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 靶点:

  IC50: 93 nM (NMDA receptor)[1]

• 参考文献:

  [1]. Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46.

  [2]. White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32.

conantokin R物理化学性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₁₂₇H₂₀₁N₃₅O₄₉S₃
• 分子量: 3098.35
• 精确质量: 3096.347412
• LogP: -8.16
• InChIKey: MJQQZSPLVNQFRB-HHXUSTKESA-N
• SMILES: CCC(C)C(NC(=O)C(CC(N)=O)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CN)C(C)C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC1CSSCC(C(=O)NC(Cc2ccc(O)cc2)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC(N)=O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC1=O
• 折射率: 1.675

conantokin R英文别名

• Glycinamide, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl 
-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-[[[(1S)-2-[(2S)-2-carboxy-1-pyrrolidinyl]-1-[(4-hydroxyphenyl)m ;ethyl]-2-oxoethyl]amino]carbonyl]-10-(1-meth
• Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L- 
α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propany ;l]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo