conantokin R
Modify Date: 2025-08-24 17:44:36
conantokin R structure
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Common Name | conantokin R | ||
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| CAS Number | 202925-60-8 | Molecular Weight | 3098.35 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C127H201N35O49S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of conantokin RConantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2]. |
| Name | Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propanyl]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo |
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| Synonym | More Synonyms |
| Description | Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2]. |
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| Related Catalog | |
| Target |
IC50: 93 nM (NMDA receptor)[1] |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C127H201N35O49S3 |
| Molecular Weight | 3098.35 |
| Exact Mass | 3096.347412 |
| LogP | -8.16 |
| Index of Refraction | 1.675 |
| InChIKey | MJQQZSPLVNQFRB-HHXUSTKESA-N |
| SMILES | CCC(C)C(NC(=O)C(CC(N)=O)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CC(C(=O)O)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CN)C(C)C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC1CSSCC(C(=O)NC(Cc2ccc(O)cc2)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC(N)=O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC1=O |
| Glycinamide, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl 
-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-[[[(1S)-2-[(2S)-2-carboxy-1-pyrrolidinyl]-1-[(4-hydroxyphenyl)m ;ethyl]-2-oxoethyl]amino]carbonyl]-10-(1-meth |
| Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L- 
α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propany ;l]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo |