TNIK inhibitor X
Modify Date: 2025-03-12 11:36:38
TNIK inhibitor X structure
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Common Name | TNIK inhibitor X | ||
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| CAS Number | 933886-36-3 | Molecular Weight | 395.437 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H17N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TNIK inhibitor XTNIK inhibitor X is a potent inhibitor of Traf2- and Nck-interacting kinase (TNIK) (in vitro enzyme IC50=9 nM) with a reasonable selectivity over 30-folds against the majority of a panel of 50 kinases profiled; inhibits cell viability of PAMC82 and T47D cells harboring TNIK amplification with IC50 of 1.77 and 0.385 uM, respectively; shows no inhibitory activity against TNIK-non-amplified AZ-521 cells (IC50>30 uM); suppresses pAKT and induction of LC3 in TNIK-amplified PAMC82 cells, shows minimal effects on either Wnt signaling-mediated transcription. |
| Name | TNIK inhibitor X |
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| Description | TNIK inhibitor X is a potent inhibitor of Traf2- and Nck-interacting kinase (TNIK) (in vitro enzyme IC50=9 nM) with a reasonable selectivity over 30-folds against the majority of a panel of 50 kinases profiled; inhibits cell viability of PAMC82 and T47D cells harboring TNIK amplification with IC50 of 1.77 and 0.385 uM, respectively; shows no inhibitory activity against TNIK-non-amplified AZ-521 cells (IC50>30 uM); suppresses pAKT and induction of LC3 in TNIK-amplified PAMC82 cells, shows minimal effects on either Wnt signaling-mediated transcription. |
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| References | References 1. Yu DH, et al. Oncogenesis. 2014 Feb 24;2:e89. 2. Yamada T, et al. TNIK inhibitor and the use. W02010/064111A1. View Related Products by Target TNIK |
| Molecular Formula | C19H17N5O3S |
|---|---|
| Molecular Weight | 395.437 |
| InChIKey | OOYMGIRITPQNDA-UHFFFAOYSA-N |
| SMILES | CC(=O)Nc1ccc(C(=O)Nc2sc(Nc3ccccc3)nc2C(N)=O)cc1 |