2095719-90-5

2095719-90-5 structure

Name: Astex ERK inhibitor X
Chemical Name: ERK1/2 inhibitor 1
CAS Number: 2095719-90-5
Molecular Formula: C₂₉H₃₂ClN₅O₄
Molecular Weight: 550.05
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2019-03-30 16:02:34
Modify Date: 2024-01-06 12:44:49
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].

Name	ERK1/2 inhibitor 1

Description	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK2:3.0 nM (IC50) ERK1
In Vitro	ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].
References	[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.