Astex ERK inhibitor X
Modify Date: 2025-08-25 14:01:25
Astex ERK inhibitor X structure
|
Common Name | Astex ERK inhibitor X | ||
|---|---|---|---|---|
| CAS Number | 2095719-90-5 | Molecular Weight | 550.05 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H32ClN5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Astex ERK inhibitor XERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1]. |
| Name | ERK1/2 inhibitor 1 |
|---|
| Description | ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK2:3.0 nM (IC50) ERK1 |
| In Vitro | ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1]. |
| References |
| Molecular Formula | C29H32ClN5O4 |
|---|---|
| Molecular Weight | 550.05 |
| InChIKey | XHOJEECXVUMYMF-IQGLISFBSA-N |
| SMILES | Cc1cccc(C(CO)NC(=O)C(C)N2Cc3ccc(-c4nc(NC5CCOCC5)ncc4Cl)cc3C2=O)c1 |
| Storage condition | -20°C |