(E/Z)-BIO-acetoxime
Modify Date: 2024-01-08 16:40:54
(E/Z)-BIO-acetoxime structure
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Common Name | (E/Z)-BIO-acetoxime | ||
|---|---|---|---|---|
| CAS Number | 740841-15-0 | Molecular Weight | 398.21000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H12BrN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (E/Z)-BIO-acetoxime(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1]. |
| Name | 6-bromoindirubin-3'-acetoxime |
|---|---|
| Synonym | More Synonyms |
| Description | (E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1]. |
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| Related Catalog | |
| Target |
GSK-3α:10 nM (IC50) GSK-3β:10 nM (IC50) Cdk5/p25:2.4 μM (IC50) CDK2/cyclinA:4.3 μM (IC50) CDK1/cyclinB:63 μM (IC50) |
| In Vitro | E/Z)-BIO-acetoxime (compound 13) shows more than 200-flod selectivity for GSK-3α/β over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, with IC50s of 0.01, 2.4, 4.3 and 63 μM, respectively[1]. |
| References |
| Molecular Formula | C18H12BrN3O3 |
|---|---|
| Molecular Weight | 398.21000 |
| Exact Mass | 397.00600 |
| PSA | 79.79000 |
| LogP | 3.78120 |
| 6-bromoindirubin-3'-acetoxime |
| GSK-3 INHIBITOR X |