10-DEBC hydrochloride

Modify Date: 2024-01-18 13:50:42

10-DEBC hydrochloride structure	Common Name	10-DEBC hydrochloride
	CAS Number	925681-41-0	Molecular Weight	381.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₆Cl₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 10-DEBC hydrochloride

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound[1][2].

Name	10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride
Synonym	More Synonyms

Description	10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	10-DEBC is found to inhibit the growth of Mtb in whole-cell assay with an IC50 of 12.8 μM, while inhibiting replication of Mtb inside iMACs with an IC50 of 1.5 μM, without host cell toxicity even at the highest concentration of 25 μM[2].
References	[1]. Wei Li, et al. More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors. Medicinal Chemistry Communications. [2]. Hyo-Won Han, et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13(6):980-991.

4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethyl-1-butanamine hydrochloride (1:1)

10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride (1:1)

AKT INHIBITOR X

10-DEBC hydrochloride

4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride (1:1)

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