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10-DEBC hydrochloride

Names

[ CAS No. ]:
925681-41-0

[ Name ]:
10-DEBC hydrochloride

[Synonym ]:
4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethyl-1-butanamine hydrochloride (1:1)
10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride (1:1)
AKT INHIBITOR X
10-DEBC hydrochloride
4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride (1:1)

Biological Activity

[Description]:

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

10-DEBC is found to inhibit the growth of Mtb in whole-cell assay with an IC50 of 12.8 μM, while inhibiting replication of Mtb inside iMACs with an IC50 of 1.5 μM, without host cell toxicity even at the highest concentration of 25 μM[2].

[References]

[1]. Wei Li, et al. More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors. Medicinal Chemistry Communications.

[2]. Hyo-Won Han, et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13(6):980-991.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H26Cl2N2O

[ Molecular Weight ]:
381.34

[ Exact Mass ]:
380.142212

[ PSA ]:
15.71000

[ LogP ]:
6.57280

[ Storage condition ]:
-20℃

Related Compounds