PSB 10 hydrochloride
Modify Date: 2025-09-09 10:19:17
PSB 10 hydrochloride structure
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Common Name | PSB 10 hydrochloride | ||
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| CAS Number | 591771-91-4 | Molecular Weight | 435.13500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H15Cl4N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PSB 10 hydrochloridePSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2]. |
| Name | PSB 10 hydrochloride,8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-onemonohydrochloride |
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| Synonym | More Synonyms |
| Description | PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2]. |
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| Related Catalog | |
| Target |
Ki: 0.44 nM (hA3AR)[2] |
| In Vitro | PSB-10 hydrochloride exhibits a subnanomolar Ki value (Ki=0.43 nM versus [3H]NECA) for A3AR. In addition, R-8 is highly selective (>800-fold) versus the other AR subtypes[1]. |
| In Vivo | PSB-10 hydrochloride (50-100 mg/kg; i.p.) dose-dependently decreases hot-plate response latencies in mice[2]. |
| References |
| Molecular Formula | C16H15Cl4N5O |
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| Molecular Weight | 435.13500 |
| Exact Mass | 433.00300 |
| PSA | 67.97000 |
| LogP | 3.62080 |
| psb 10 hydrochloride |