Ciprofloxacin Hydrochloride
Modify Date: 2024-01-02 18:14:36
Ciprofloxacin Hydrochloride structure
|
Common Name | Ciprofloxacin Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 93107-08-5 | Molecular Weight | 367.802 | |
| Density | N/A | Boiling Point | 581.8ºC at 760 mmHg | |
| Molecular Formula | C17H19ClFN3O3 | Melting Point | >300ºC | |
| MSDS | N/A | Flash Point | 305.6ºC | |
Use of Ciprofloxacin HydrochlorideCiprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. |
| Name | Ciprofloxacin (hydrochloride) |
|---|---|
| Synonym | More Synonyms |
| Description | Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. |
|---|---|
| Related Catalog | |
| Target |
Bacterial[1] |
| In Vitro | Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1]. Ciprofloxacin hydrochloride (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. |
| In Vivo | Ciprofloxacin hydrochloride (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin hydrochloride (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[1]. In a murine model of pneumonic plague, Ciprofloxacin hydrochloride (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin hydrochloride. Intraperitoneal Ciprofloxacin hydrochloride reduces the lung bacterial load compare to controls treated with intraperitoneal PBS[3]. |
| Cell Assay | Bacterial inocula are prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containing Ciprofloxacin hydrochloride) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar (SBA) plates that are incubated at 35°C. Suspended cultures are diluted with CAMHB to a bacterial cell density of 105 CFU/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50 μL of dilutions is added for a final inoculum of ~5×104 CFU/well. Plates are incubated at 35°C. MICs are determined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm[2]. |
| Animal Admin | Female BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (±4 g) are used in this assay. A single dose of Ciprofloxacin hydrochloride (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following Ciprofloxacin hydrochloride administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of Ciprofloxacin hydrochloride and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of Ciprofloxacin hydrochloride in the lung samples at 1 min post-administration[3]. |
| References |
| Boiling Point | 581.8ºC at 760 mmHg |
|---|---|
| Melting Point | >300ºC |
| Molecular Formula | C17H19ClFN3O3 |
| Molecular Weight | 367.802 |
| Flash Point | 305.6ºC |
| Exact Mass | 367.109894 |
| PSA | 74.57000 |
| LogP | 2.77910 |
| Storage condition | 2-8C |
| Hazard Codes | Xi:Irritant; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| HS Code | 29419000 |
| Precursor 10 | |
|---|---|
| DownStream 5 | |
CAS#:85721-33-1
CAS#:86393-32-0
CAS#:110-85-0
CAS#:93107-30-3
CAS#:86393-33-1
CAS#:67-68-5
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CAS#:86393-34-2
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CAS#:93594-39-9
CAS#:105093-21-8
CAS#:105394-83-0| HS Code | 29419000 |
|---|
| 1-Cyclopropyl-6-fluor-4-oxo-7-piperazin-1-yl-1,4-dihydrochinolin-3-carbonsäurehydrochlorid |
| 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride (1:1) |
| 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acid hydrochloride |
| 1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1) |
| ciprofloxacinium chloride |
| 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1) |
| acide 1-cyclopropyl-6-fluoro-4-oxo-7-pipérazin-1-yl-1,4-dihydroquinoléine-3-carboxylique chlorhydrate |
| Cyproxan |
| 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride |
| Ciprofloxacin Hydrochloride |
| 4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazin-1-ium chloride |
| ciprofloxacin monohydrochloride |
| 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid |
| Ciprofloxacin Hcl |
| BAY-o-9867 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ciprofloxacin Hydrochloride
- Price: ￥168.0/100mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Ciprofloxacin hydrochloride
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-(PIPERAZIN-1-YL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Ciprofloxacin
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Ciprofloxacin HCl
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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