|CAS Number||85721-33-1||Molecular Weight||331.341|
|Density||1.5±0.1 g/cm3||Boiling Point||581.8±50.0 °C at 760 mmHg|
|Molecular Formula||C17H18FN3O3||Melting Point||255-257°C|
|MSDS||Chinese USA||Flash Point||305.6±30.1 °C|
Use of Ciprofloxacin
Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
|Description||Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.|
|In Vitro||Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL.|
|In Vivo||Ciprofloxacin (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin. Intraperitoneal Ciprofloxacin reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.|
DMSO : < 1 mg/mL (insoluble or slightly soluble)
|Cell Assay||Bacterial inocula are prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containing Ciprofloxacin) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar (SBA) plates that are incubated at 35°C. Suspended cultures are diluted with CAMHB to a bacterial cell density of 105 CFU/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50 μL of dilutions is added for a final inoculum of ~5×104 CFU/well. Plates are incubated at 35°C. MICs are determined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm.|
|Animal Admin||Female BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (±4 g) are used in this assay. A single dose of Ciprofloxacin (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following Ciprofloxacin administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of Ciprofloxacin and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of Ciprofloxacin in the lung samples at 1 min post-administration.|
4°C, protect from light
|Shipping||Room temperature in continental US; may vary elsewhere|
|Related Molecules||Puromycin dihydrochloride | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium|
*The above documents are provided by Medchemexpress and are for scientific research only.
|Boiling Point||581.8±50.0 °C at 760 mmHg|
|Flash Point||305.6±30.1 °C|
|Vapour Pressure||0.0±1.7 mmHg at 25°C|
|Index of Refraction||1.655|
|Storage condition||Store at 0-5°C|
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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