Ciprofloxacin
Ciprofloxacin structure
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Common Name | Ciprofloxacin | ||
|---|---|---|---|---|
| CAS Number | 85721-33-1 | Molecular Weight | 331.341 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 581.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H18FN3O3 | Melting Point | 255-257°C | |
| MSDS | Chinese USA | Flash Point | 305.6±30.1 °C | |
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A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the Xin repeats is required for maintenance of stereocilia morphology and hearing function.
J. Neurosci. 35(5) , 1999-2014, (2015) Approximately one-third of known deafness genes encode proteins located in the hair bundle, the sensory hair cell's mechanoreceptive organelle. In previous studies, we used mass spectrometry to characterize the hair bundle's proteome, resulting in the discove... |
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NADPH oxidase expression and production of superoxide by human corneal stromal cells.
Mol. Vis. 15 , 2535-43, (2009) Superoxide (O(2) (.-)) may function as a second messenger or regulator of signal transduction when produced at low concentrations in the proper locations within cells. The purpose of these studies was to determine whether human corneal stromal (HCS) fibroblas... |
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Genotypes and oxacillin resistance of Staphylococcus aureus from chicken and chicken meat in Poland.
Poult. Sci. 93(12) , 3179-86, (2014) The genotypes and oxacillin resistance of 263 Staphylococcus aureus isolates cultured from chicken cloacae (n = 138) and chicken meat (n = 125) was analyzed. Fifteen spa types were determined in the studied S. aureus population. Among 5 staphylococcal protein... |
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Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.
Antimicrob. Agents Chemother. 51 , 2445-53, (2007) Heteroaryl isothiazolones (HITZs) are antibacterial agents that display excellent in vitro activity against Staphylococcus aureus. We recently identified a series of these compounds that show potent bactericidal activities against methicillin-resistant Staphy... |
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In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens.
Antimicrob. Agents Chemother. 51 , 1259-67, (2007) The activities of several tricyclic heteroaryl isothiazolones (HITZs) against an assortment of gram-positive and gram-negative clinical isolates were assessed. These compounds target bacterial DNA replication and were found to possess broad-spectrum activitie... |
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Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy.
Antimicrob. Agents Chemother. 54 , 1007-15, (2010) AcrAB-TolC imparts a strong intrinsic resistance phenotype to many clinically significant molecules in Escherichia coli. This complex is composed of a pump, AcrB, and a periplasmic protein, AcrA, that exports substrates through a common outer membrane porin, ... |
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Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli.
Antimicrob. Agents Chemother. 54 , 506-8, (2010) Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of alpha-h... |
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RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine.
Antimicrob. Agents Chemother. 52 , 3604-11, (2008) Salmonella enterica serovar Typhimurium SL1344, in which efflux pump genes (acrB, acrD, acrF, tolC) or regulatory genes thereof (marA, soxS, ramA) were inactivated, was grown in the presence of 240 antimicrobial and nonantimicrobial agents in the Biolog Pheno... |
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In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.
Antimicrob. Agents Chemother. 54 , 1955-64, (2010) JNJ-Q2, a novel fluorinated 4-quinolone, was evaluated for its antibacterial potency by broth and agar microdilution MIC methods in studies focused on skin and respiratory tract pathogens, including strains exhibiting contemporary fluoroquinolone resistance p... |
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Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae.
Antimicrob. Agents Chemother. 55 , 190-6, (2011) Fifty-seven clinical isolates of Streptococcus pneumoniae were divided into four groups based on their susceptibilities to the fluoroquinolones ciprofloxacin and norfloxacin and the dyes ethidium bromide and acriflavine. Comparative reverse transcription-PCR ... |