Neuromedin N trifluoroacetate salt

Modify Date: 2024-01-02 18:53:28

Neuromedin N trifluoroacetate salt structure	Common Name	Neuromedin N trifluoroacetate salt
	CAS Number	92169-45-4	Molecular Weight	745.94900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₈H₆₃N₇O₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Neuromedin N trifluoroacetate salt

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Sequence: Lys-Ile-Pro-Tyr-Ile-Leu.

Name	2-[[2-[[2-[[1-[2-(2,6-diaminohexanoylamino)-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Synonym	More Synonyms

Description	Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Sequence: Lys-Ile-Pro-Tyr-Ile-Leu.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Peptides
Target	Dopamine D2 receptor[1].
In Vitro	Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].
References	[1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4. [2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44.

Molecular Formula	C₃₈H₆₃N₇O₈
Molecular Weight	745.94900
Exact Mass	745.47400
PSA	246.28000
LogP	4.44620
Storage condition	-20°C

Boc-L-Proline structure

Boc-L-Proline

CAS#:15761-39-4

Boc-L-Isoleucine structure

Boc-L-Isoleucine

CAS#:13139-16-7

Boc-Lys(Fmoc)-OH structure

Boc-Lys(Fmoc)-OH

CAS#:84624-27-1

N/A structure

N/A

CAS#:128797-22-8

~%

Detail

Literature: Kiso; Kimura; Fujiwara; Sakikawa; Akaji Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 270 - 272

Precursor 3
CAS#:15761-39-4 Boc-L-Proline CAS#:13139-16-7 Boc-L-Isoleucine CAS#:84624-27-1 Boc-Lys(Fmoc)-OH
DownStream 0

neuromedin N

Lys-ile-pro-tyr-ile-leu

GL Biochem (Shanghai) Ltd.
China
Product Name: Neuromedin N;KIPYIL-NH2
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

DC Chemicals Limited
China
Product Name: Neuromedin N
Price: $550.0/100mg $950.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: NEUROMEDIN N
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Neuromedin N
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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Price: $177/10mM*1mLinDMSO

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