117505-80-3

117505-80-3 structure

Name: Neuromedin U-23 (rat) trifluoroacetate salt
Chemical Name: Neuromedin U (rat)
CAS Number: 117505-80-3
Molecular Formula: C₁₂₄H₁₈₀N₃₄O₃₁
Molecular Weight: 2642.97000
Catalog: Peptides
Create Date: 2018-12-27 17:01:24
Modify Date: 2024-01-19 21:17:21
Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

Name	Neuromedin U (rat)
Synonyms	H-Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser H-TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2 NMU,RAT YKVNEYQGPVAPSGGFFLFRPRN-NH2 TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2 NMU-23 neuromedin U TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2 Neuromedin U, rat

Description	Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Peptides
Target	NMUR2[1]
In Vitro	To establish an electrochemiluminescent (ECL) binding assay for NMUR2 receptor, the peptide Neuromedin U (NMU-23) is labeled at the N terminus with Ru(bpy)2+3 and allowed to bind to the human NMUR2 receptor in the cell membranes immobilized on the electrode on the bottom of each assay plate. Upon application of an electric current, the receptor-bound Ru(bpy)2+3-ligand undergoes an oxidation-reduction cycle in the presence of a coreactant tripropylamine and emits light. Signal is only generated when the Ru(bpy)2+3 label is in proximity to the electrode, thus discriminating the bound label from the unbound and enabling a no wash, homogenous assay format. The ECL-based NMUR2 binding assay is used to screen our corporate compound collection. Approximately 670,000 compounds with diverse structures are tested at 10 μM for their ability to displace the binding of 0.5 nM Ru(bpy)2+3-NMU-23 to human NMUR2 receptors. From competition binding experiments, the Ki values for NMU-23 is determined to be 4.7 nM[1].
References	[1]. Liu JJ, et al. Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. J Pharmacol Exp Ther. 2009 Jul;330(1):268-75.

Molecular Formula	C₁₂₄H₁₈₀N₃₄O₃₁
Molecular Weight	2642.97000
Exact Mass	2641.36000
PSA	1060.02000
LogP	4.23350
Storage condition	2-8℃

Safety Phrases	22-24/25
WGK Germany	3

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