TC-I 15

Modify Date: 2025-09-09 11:55:58

TC-I 15 Structure
TC-I 15 structure
Common Name TC-I 15
CAS Number 916734-43-5 Molecular Weight 520.62
Density 1.364±0.06 g/cm3 (20 °C, 760 mmHg) Boiling Point N/A
Molecular Formula C23H28N4O6S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TC-I 15


TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition[1].

 Names

Name L-Alanine, N-[[(4R)-5,5-dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]
Synonym More Synonyms

 TC-I 15 Biological Activity

Description TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition[1].
Related Catalog
Target

α2β1:0.4 (α2β1 μM (IC50)

α2β1:26.8 (α2β1 μM (IC50)

α1β1:23.6 (α1β1 μM (IC50)

α1β1:24.4 (α1β1 μM (IC50)

α11β1:177 (α11β1 μM (IC50)

α11β1:3177 (α11β μM (IC50)

References

[1]. Emma J. Hunter, Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol Appl Pharmacol. 2021 Oct 1;428:115669.

 Chemical & Physical Properties

Density 1.364±0.06 g/cm3 (20 °C, 760 mmHg)
Molecular Formula C23H28N4O6S2
Molecular Weight 520.62
Exact Mass 520.14500
PSA 178.59000
LogP 3.78900

 Synonyms

Piclamilast
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