TC-I 2014

Modify Date: 2024-01-13 17:03:07

TC-I 2014 Structure
TC-I 2014 structure
Common Name TC-I 2014
CAS Number 1221349-53-6 Molecular Weight 467.41
Density N/A Boiling Point N/A
Molecular Formula C23H19F6N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TC-I 2014


TC-I 2014 (compound 5) is a potent Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].

 Names

Name TC-I 2014

 TC-I 2014 Biological Activity

Description TC-I 2014 (compound 5) is a potent Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].
Related Catalog
Target

TRPM8[1].

References

[1]. Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.

 Chemical & Physical Properties

Molecular Formula C23H19F6N3O
Molecular Weight 467.41