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TC-I 15

Names

[ CAS No. ]:
916734-43-5

[ Name ]:
TC-I 15

[Synonym ]:
Piclamilast

Biological Activity

[Description]:

TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Cytoskeleton >> Integrin

[Target]

α2β1:0.4 (α2β1 μM (IC50)

α2β1:26.8 (α2β1 μM (IC50)

α1β1:23.6 (α1β1 μM (IC50)

α1β1:24.4 (α1β1 μM (IC50)

α11β1:177 (α11β1 μM (IC50)

α11β1:3177 (α11β μM (IC50)


[References]

[1]. Emma J. Hunter, Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol Appl Pharmacol. 2021 Oct 1;428:115669.

Chemical & Physical Properties

[ Density]:
1.364±0.06 g/cm3 (20 °C, 760 mmHg)

[ Molecular Formula ]:
C23H28N4O6S2

[ Molecular Weight ]:
520.62

[ Exact Mass ]:
520.14500

[ PSA ]:
178.59000

[ LogP ]:
3.78900

Related Compounds

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