Thrombin

Modify Date: 2024-01-04 19:56:11

Thrombin Structure
Thrombin structure
Common Name Thrombin
CAS Number 9002-04-4 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger

 Use of Thrombin


Thrombin is a trypsin-like allosteric serine protease that has a fundamental role in the clotting cascade.

 Names

Name Thrombin
Synonym More Synonyms

 Thrombin Biological Activity

Description Thrombin is a trypsin-like allosteric serine protease that has a fundamental role in the clotting cascade.
Related Catalog
In Vitro Thrombin is a serine protease known to have a fundamental role in the clotting cascade. In addition, Thrombin also mediates several cellular processes through a unique family of protease-activated receptors (PARS), where PAR-1 is the prototype. Thrombin and PAR-1 are highly expressed in the brain and regulate synaptic transmission and plasticity[1]. Thrombin belongs to the chymotrypsin family and is generated by proteolytic cleavage of its inactive precursor prothrombin by the proThrombinase complex. Thrombin mediates the conversion of fibrinogen to fibrin, the main constituent of a blood clot. Furthermore, Thrombin activates the blood coagulation factors V, VIII, XI, XIII and the anticoagulant protein C[2].
References

[1]. Golderman V, et al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2018 Dec 4.

[2]. Krenzlin H, et al. The Importance of Thrombin in Cerebral Injury and Disease. Int J Mol Sci. 2016 Jan 11;17(1).

 Chemical & Physical Properties

Appearance of Characters powder | white
Storage condition −20°C
Water Solubility H2O: 1 mL/vial clear to slightly hazy, colorless solution

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H315-H319-H334-H335
Precautionary Statements P261-P305 + P351 + P338-P342 + P311
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn,B,Xi
Risk Phrases 36/37/38-42
Safety Phrases 22-24/25-36/37-26-24
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS XO8950000

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 Synonyms

EINECS 232-648-7
MFCD00166053
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