3,4,5-Trimethoxycinnamic acid

Modify Date: 2024-01-02 09:39:39

3,4,5-Trimethoxycinnamic acid structure	Common Name	3,4,5-Trimethoxycinnamic acid
	CAS Number	90-50-6	Molecular Weight	238.237
	Density	1.2±0.1 g/cm3	Boiling Point	396.4±37.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₄O₅	Melting Point	125-127 °C(lit.)
	MSDS	Chinese USA	Flash Point	151.5±20.0 °C

Use of 3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

Name	3,4,5-trimethoxycinnamic acid
Synonym	More Synonyms

Description	3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Phenylpropanoids Research Areas >> Neurological Disease
Target	γ-subunit of GABAA receptor[2]
In Vitro	3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
In Vivo	3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1]. 3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].
References	[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9. [2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

Density	1.2±0.1 g/cm3
Boiling Point	396.4±37.0 °C at 760 mmHg
Melting Point	125-127 °C(lit.)
Molecular Formula	C₁₂H₁₄O₅
Molecular Weight	238.237
Flash Point	151.5±20.0 °C
Exact Mass	238.084122
PSA	64.99000
LogP	2.00
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.560

3,4,5-Trimethoxycinnamic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GE0722000

CHEMICAL NAME :: Cinnamic acid, 3,4,5-trimethoxy-

CAS REGISTRY NUMBER :: 90-50-6

BEILSTEIN REFERENCE NO. :: 1537834

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H14-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 422 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	GE0722000
HS Code	2916399090

Precursor 0
DownStream 6
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HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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3,4,5-Trimethoxycinnamic

o-methylsinapicacid

3,4,5-Trimethoxy cinnamic acid

(2E)-3-(3,4,5-Trimethoxyphenyl)acrylic acid

2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, (2E)-

3,4,5-Trimethoxycinnamic acid

2-propenoic acid, 3-(3,4,5-trimethoxyphenyl)-

TRIMETHOXYCINNAMICACID

3,4,5-trimethoxy-cinnamicaci

5-TriMethoxycinnaMic acid

3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

EINECS 201-999-8

3,4,5-Trimethoxyzimtsure

RARECHEM BK HC T328

MFCD00004388

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: ￥468.0/100g ￥158.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 3,4,5-Trimethoxycinnamic acid
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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