90-50-6

90-50-6 structure

Name: 3,4,5-Trimethoxycinnamic acid
Chemical Name: 3,4,5-trimethoxycinnamic acid
CAS Number: 90-50-6
Molecular Formula: C₁₂H₁₄O₅
Molecular Weight: 238.237
Catalog: Flavors and spices Synthetic spice Aromatic cinnamic acid, esters and derivatives
Create Date: 2018-04-21 08:00:00
Modify Date: 2025-08-21 08:58:15
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

Name	3,4,5-trimethoxycinnamic acid
Synonyms	3,4,5-Trimethoxycinnamic o-methylsinapicacid 3,4,5-Trimethoxy cinnamic acid (2E)-3-(3,4,5-Trimethoxyphenyl)acrylic acid 2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, (2E)- 3,4,5-Trimethoxycinnamic acid 2-propenoic acid, 3-(3,4,5-trimethoxyphenyl)- TRIMETHOXYCINNAMICACID 3,4,5-trimethoxy-cinnamicaci 5-TriMethoxycinnaMic acid 3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid EINECS 201-999-8 3,4,5-Trimethoxyzimtsure RARECHEM BK HC T328 MFCD00004388

Description	3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Phenylpropanoids Research Areas >> Neurological Disease
Target	γ-subunit of GABAA receptor[2]
In Vitro	3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
In Vivo	3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1]. 3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].
References	[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9. [2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	GE0722000
HS Code	2916399090

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%