CNT2 inhibitor-1

Modify Date: 2025-08-25 19:57:45

Use of CNT2 inhibitor-1

CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

Name	CNT2 inhibitor-1

Description	CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
Target	IC50: 640 nM (hCNT2)[1][2].
In Vitro	CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors[1]. CNT2 inhibitor-1 (compound 1) is a potent inhibitor with poor solubility[2].
References	[1]. Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8.

Molecular Formula	C₂₃H₂₄N₆O₄
Molecular Weight	448.47
InChIKey	YJLIKUSWRSEPSM-WGQQHEPDSA-N
SMILES	Nc1ncnc2c1nc(NCc1ccc(-c3ccccc3)cc1)n2C1OC(CO)C(O)C1O
Storage condition	2-8℃

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Price: ￥6050/10 mM * 1 mL in DMSO

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