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880155-70-4

880155-70-4 structure
880155-70-4 structure
  • Name: CNT2 inhibitor-1
  • Chemical Name: CNT2 inhibitor-1
  • CAS Number: 880155-70-4
  • Molecular Formula: C23H24N6O4
  • Molecular Weight: 448.47
  • Catalog: Research Areas Others
  • Create Date: 2019-01-20 21:32:03
  • Modify Date: 2024-01-08 17:47:43
  • CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

Name CNT2 inhibitor-1
Description CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.
Related Catalog
Target

IC50: 640 nM (hCNT2)[1][2].

In Vitro CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors[1]. CNT2 inhibitor-1 (compound 1) is a potent inhibitor with poor solubility[2].
References

[1]. Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8.

Molecular Formula C23H24N6O4
Molecular Weight 448.47
Storage condition 2-8℃