Medetomidine

Modify Date: 2025-08-26 19:14:34

Medetomidine structure	Common Name	Medetomidine
	CAS Number	86347-14-0	Molecular Weight	200.279
	Density	1.1±0.1 g/cm3	Boiling Point	381.9±11.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₆N₂	Melting Point	151.5 - 152.5ºC
	MSDS	N/A	Flash Point	191.3±5.7 °C

Use of Medetomidine

Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Name	medetomidine
Synonym	More Synonyms

Description	Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Wenger S, Hoby S, Wyss F, Adami C, Wenker C. Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride. Vet Anaesth Analg. 2012 Aug 8. doi: 10.1111/j.1467-2995.2012.00761.x. [2]. Gerritsmann H, Stalder GL, Seilern-Moy K, Knauer F, Walzer C. Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus). Vet Anaesth Analg. 2012 Jul 13. doi: 10.1111/j.1467-2995.2012. [3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5. [4]. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14. [5]. Stenberg D, Salvén P, Miettinen MV. Sedative action of the alpha 2-agonist medetomidine in cats. J Vet Pharmacol Ther. 1987 Dec;10(4):319-23.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

References

[1]. Wenger S, Hoby S, Wyss F, Adami C, Wenker C. Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride. Vet Anaesth Analg. 2012 Aug 8. doi: 10.1111/j.1467-2995.2012.00761.x.

[2]. Gerritsmann H, Stalder GL, Seilern-Moy K, Knauer F, Walzer C. Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus). Vet Anaesth Analg. 2012 Jul 13. doi: 10.1111/j.1467-2995.2012.

[3]. Kallio A, Koulu M, Scheinin H, Viikari J, Scheinin M. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5.

[4]. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14.

[5]. Stenberg D, Salvén P, Miettinen MV. Sedative action of the alpha 2-agonist medetomidine in cats. J Vet Pharmacol Ther. 1987 Dec;10(4):319-23.

Density	1.1±0.1 g/cm3
Boiling Point	381.9±11.0 °C at 760 mmHg
Melting Point	151.5 - 152.5ºC
Molecular Formula	C₁₃H₁₆N₂
Molecular Weight	200.279
Flash Point	191.3±5.7 °C
Exact Mass	200.131348
PSA	28.68000
LogP	3.10
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.570
Storage condition	-20°C

HS Code	2933290090

Precursor 8
CAS#:86347-15-1 Medetomidine HCl CAS#:60907-90-6 Benzenemethanol... CAS#:18156-74-6 N-(Trimethylsil... CAS#:576-23-8 2,3-Dimethylbro...
CAS#:176721-02-1 (2,3-DIMETHYLPH... CAS#:176721-01-0 α-(2,3-Dimethyl... CAS#:603-79-2 DIMETHYLBENZOIC ACID CAS#:21900-46-9 2,3-Dimethylben...
DownStream 1
CAS#:86347-15-1 Medetomidine HCl

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Medetomidine

1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-

Medetomidina

4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole

Medetomidine [inn:ban]

(rac)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole

Medetomidinum

4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole

Medetomidina [spanish]

DoMtor

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Medetomidine

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