86347-14-0
86347-14-0 structure
- Name: Medetomidine
- Chemical Name: medetomidine
- CAS Number: 86347-14-0
- Molecular Formula: C13H16N2
- Molecular Weight: 200.279
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2018-07-14 13:55:02
- Modify Date: 2025-08-26 19:14:34
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Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
| Name | medetomidine |
|---|---|
| Synonyms |
Medetomidine
1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]- Medetomidina 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Medetomidine [inn:ban] (rac)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole Medetomidinum 4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole Medetomidina [spanish] DoMtor |
| Description | Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). IC50 value:Target: α2-adrenoceptorMedetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 381.9±11.0 °C at 760 mmHg |
| Melting Point | 151.5 - 152.5ºC |
| Molecular Formula | C13H16N2 |
| Molecular Weight | 200.279 |
| Flash Point | 191.3±5.7 °C |
| Exact Mass | 200.131348 |
| PSA | 28.68000 |
| LogP | 3.10 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.570 |
| Storage condition | -20°C |
| HS Code | 2933290090 |
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| Precursor 8 | |
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| DownStream 1 | |
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |